Bromodomain-containing protein 4

Basic Information

Uniprot ID:	O60885
Secondary ID:	O60433
Symbol:	BRD4
Other Name:	HUNK1,Protein HUNK1
Class:	Epigenetics
Type:	pro-fibrotic
Molecular Function:	Chromatin regulator

Target Classification

Category I	Category II	Category III
Intracellular	Epigenetics	Reader

Related Compound

Target ID	Name	Interaction
D0091	JQ1	antagonist

Fibrosis Related Property

Reference Record 1

PubMed ID	28063381	Compound ID	D0091
CAS	1268524-70-4	Name	JQ1
Model	vitro,rat	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting TGF-β-Nox4-ROS

Reference Record 2

PubMed ID	27793799	Compound ID	D0091
CAS	1268524-70-4	Name	JQ1
Model	vitro,mice	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II	EMT
Process III	prevenet collagen deposition
Mechanism	Targeting NF-κB-dependent

Reference Record 3

PubMed ID	27240956	Compound ID	D0091
CAS	1268524-70-4	Name	JQ1
Model	vitro	Fibrosis Disease	Cystic fibrosis
Process I
Process II
Process III
Mechanism	Targeting CXCL8

Reference Record 4

PubMed ID	26644586	Compound ID	D0091
CAS	1268524-70-4	Name	JQ1
Model	vitro,mice	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs activation
Process III
Mechanism