Sphingomyelin phosphodiesterase

Basic Information

Uniprot ID:	P17405
Secondary ID:	A8K8M3
Symbol:	SMPD1
Other Name:	ASM,Acid sphingomyelinase,aSMase
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	Glycosidase,Hydrolase

Target Classification

Category I	Category II	Category III
Both	Enzyme

Related Compound

Target ID	Name	Interaction
D0041	Amlodipine	inhibitor
D0264	Amitriptyline	inhibitor
D0407	Trimipramine	inhibitor
D0408	Desipramine	inhibitor
D0409	Chlorprothixene	inhibitor
D0410	Fluoxetine	inhibitor
D0411	Sertraline	inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID	19635928	Compound ID	D0264
CAS	50-48-6	Name	Amitriptyline
Model	vitro,human,mice	Fibrosis Disease	Cystic fibrosis
Process I	attenue inflammation
Process II
Process III
Mechanism

Reference Record 2

PubMed ID	19635928	Compound ID	D0407
CAS	739-71-9	Name	Trimipramine
Model	vitro,human,mice	Fibrosis Disease	Cystic fibrosis
Process I	attenue inflammation
Process II
Process III
Mechanism

Reference Record 3

PubMed ID	19635928	Compound ID	D0408
CAS	50-47-5	Name	Desipramine
Model	vitro,human,mice	Fibrosis Disease	Cystic fibrosis
Process I	attenue inflammation
Process II
Process III
Mechanism

Reference Record 4

PubMed ID	19635928	Compound ID	D0409
CAS	113-59-7	Name	Chlorprothixene
Model	vitro,human,mice	Fibrosis Disease	Cystic fibrosis
Process I	attenue inflammation
Process II
Process III
Mechanism

Reference Record 5

PubMed ID	19635928	Compound ID	D0410
CAS	54910-89-3	Name	Fluoxetine
Model	vitro,human,mice	Fibrosis Disease	Cystic fibrosis
Process I	attenue inflammation
Process II
Process III
Mechanism

Reference Record 6

PubMed ID	19635928	Compound ID	D0041
CAS	88150-42-9	Name	Amlodipine
Model	vitro,human,mice	Fibrosis Disease	Cystic fibrosis
Process I	attenue inflammation
Process II
Process III
Mechanism

Reference Record 7

PubMed ID	19635928	Compound ID	D0411
CAS	79617-96-2	Name	Sertraline
Model	vitro,human,mice	Fibrosis Disease	Cystic fibrosis
Process I	attenue inflammation
Process II
Process III
Mechanism