Galectin-3

Basic Information

Uniprot ID: P17931
Secondary ID: B2RC38
Symbol: LGALS3
Other Name: MAC2,Gal-3,35 kDa lectin,Carbohydrate-binding protein 35,CBP 35,Galactose-specific lectin 3,Galactoside-binding protein,GALBP,IgE-binding protein,L-31,Laminin-binding protein,Lectin L-29,Mac-2 antigen
Class: Single Protein
Type: pro-fibrotic
Molecular Function: IgE-binding protein

Target Classification

Category I Category II Category III
Both Other

Related Compound

Target ID Name Interaction
D0006 N-acetyllactosamine inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 28826890 Compound ID D0006
CAS 32181-59-2 Name N-acetyllactosamine
Model human,mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II fibroblasts proliferation, fibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 28431936 Compound ID
CAS Name
Model vitro,rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 28322201 Compound ID
CAS Name
Model vitro,human,mice Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 27496875 Compound ID
CAS Name
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 27630169 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting NLRP3 inflammasome/IL-1β production and IL-17 signaling

Reference Record 6

PubMed ID 26351031 Compound ID
CAS Name
Model human,rat Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 26313861 Compound ID
CAS Name
Model human Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 8

PubMed ID 26313861 Compound ID
CAS Name
Model human Fibrosis Disease Vascular fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 9

PubMed ID 23230309 Compound ID
CAS Name
Model vitro,mice,rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID 22306573 Compound ID
CAS Name
Model mice Fibrosis Disease Renal fibrosis
Process I
Process II cells activation,cells accumulation
Process III prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID 27870162 Compound ID
CAS Name
Model vitro,rat Fibrosis Disease Vascular fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting MMP-9