DescriptionSummary statistics of "Genetic Loci Associated with Nail Plate Morphology in East Asian Populations"
Analysis typeDe Novo Assembly
OEZ017061
Analysis typeOther
OEZ017063
DescriptionMethylation quantitative trait loci (mQTLs) are essential for understanding the role of DNA methylation changes in genetic predisposition, yet they have not been fully characterized in East Asians. We identified mQTLs in whole blood from 3,523 Chinese individuals and replicated them in additional 1,858 Chinese individuals from two cohorts. Over 9% of mQTLs displayed specificity to East-Asians, facilitating the fine-mapping of EA-specific genetic associations, as shown for variants associated with height. Trans-mQTLs hotspots revealed biological pathways contributing to EA-specific genetic associations, including an ERG-mediated 233 trans-mCpG network, implicated in hematopoietic cell differentiation, which reflects binding efficiency modulation of the ERG protein complex. More than 90% of mQTLs were shared between different blood cell-lineages, with the smaller fraction of lineage-specific mQTLs displaying preferential hypomethylation in the respective lineages. Our study provides new insights into the mQTL landscape across ethnicities and their downstream effects on cellular processes and diseases/traits.
Analysis typeOther
OEZ008120
DescriptionRNA-seq and ATAC-seq data for investigating p38-MAPK signaling in MASLD-Associated Hepatocellular Carcinoma and other etiologies
Analysis typeReference Alignment
OEZ017062
Analysis typeDe Novo Assembly
OEZ014878
DescriptionThe metabolite data of Rugao 2019-follow up
Analysis typeOther
OEZ014274
Analysis typeOther
OEZ014617
DescriptionAdh: F1-pos-F6-pos; G2: F6-pos-F12-pos; G3: F13-pos-F18-pos
Analysis typeDe Novo Assembly
OEZ013883
DescriptionAdh: L1-pos-L6-pos; G2: L6-pos-L12-pos; G3: L13-pos-L18-pos
Analysis typeDe Novo Assembly
OEZ013886
DescriptionAdh: L1-neg-L6-neg; G2: L6-neg-L12-neg; G3: L13-neg-L18-neg
Analysis typeDe Novo Assembly
OEZ013885