Li Yang, Fudan University,2024.04.27

Description

Circular RNAs (circRNAs) are upregulated during neurogenesis. Where and how circRNAs are localized, and what roles they play during this process have remained elusive. By comparing the nuclear and cytoplasmic circRNAs between H9 cells and H9-derived forebrain neurons (FB), we found a subset of adenosine (A)-rich circRNAs are restricted in H9 nuclei but exported to cytosols upon forebrain neuron differentiation. This differentiation-coupled circRNA subcellular relocation is modulated by the poly(A)-binding protein PABPC1. In the nucleus, newly produced (A)-rich circRNAs are bound by PABPC1 and the nuclear basket protein TPR to prevent their nucleocytoplasmic export. Modulation of (A)-rich motifs in circRNAs remarkably alters their subcellular localization. Enforced (A)-rich circRNAs in cytosols result in mRNA translation suppression. Furthermore, decreased nuclear PABPC1 upon neuronal differentiation enables the export of (A)-rich circRNAs including circRTN4(2,3), which is required for neurite outgrowth. These findings uncover subcellular localization features of circRNAs, linking their processing and function during neurogenesis.

OEP005241

GuLan chun, Fulgent,2024.04.29

Description

20240430_WGBS

OEP005253

GuLan chun, Fulgent,2024.04.29

Description

OEP005251

Li qingmei, ,2024.04.28

Description

These are 16S rDNA sequences predicted from metagenomic reads, used for overall analysis of the prokaryotic community structure, diversity in aquatic environments, its relationship with seawater depth, and the variation of gene relative abundance with seawater depth.

OEP005246

GuLan chun, Fulgent,2024.04.28

Description

20240428_WGS

OEP005243

MengXiang You, 上海营养与健康研究所,2024.04.21

Description

Summary statistics of "Genetic Loci Associated with Nail Plate Morphology in East Asian Populations"

OEP005227

Yuting Dai, Shanghai Institute of Hematology,2024.04.26

Description

Data for Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases

OEP005239

Sijia Wang, Shanghai Institute of Nutrition and Health，Chinese Academy of Sciences,2021.11.16

Description

This project has included individual-level genotype data (SNP chip, methy_3523_qc0.01.bed,bim,fam) and DNA methylation data (Illumina EPIC, methy_3523.rdata) of 3523 Han Chinese (NSPT), and also the individual-level genotype data (SNP chip, 200505_960Sps_passed.vcf) and DNAm data (Illumina EPIC, beta_norm.rda) of additional 798 individuals (CGZ), which are in controlled access. The individual-level genotype data is not available because of IRB restriction due to privacy concern. The individual-level DNA methylation data can be available with reasonable requests. The project also included mQTL summary statistics (cis1_10.zip, cis11_22.zip, lcis.zip, trans.zip) with threshold of 1e-10 in 3523 Han Chinese (NSPT), the replication for these mQTLs (CGZ_mQTL.rep2.csv) in the CGZ cohort, and blood cell-lineage (lymphoid- and myeloid-) mQTLs estimated by using CELLDMC (cts_mQTL_info.Rd). These data are available for download. Data usage shall be in full compliance with the Regulations on Management of Human Genetic Resources in China. Use of this data requires a citation of our article. For controlled access data, requests are normally processed within two weeks. A template of the data sharing and confidentiality agreement will be sent to the applicant, and the data can be used within the permitted scope after the data sharing and confidentiality agreement has been signed.

OEP002902

Tao Zeng, Guangzhou lab,2024.04.24

Description

Multi-omics study of p38-MAPK signaling in MASLD-Associated Hepatocellular Carcinoma and other etiologies

OEP005235

Rong Tang, Fudan University Shanghai Cancer Center,2024.04.23

Description

OEP005232