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  • PROJ Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer

    Ning Wang, Shanghai Institute of Nutrition and Health, CAS,2024.01.24

    Description

    Polyamines play essential roles in both normal and cancer cell growth. Polyamine metabolism is frequently dysregulated and is considered as a therapeutic target in cancer. However, targeting polyamine metabolism as monotherapy often exhibits limited efficacy, and the underlying mechanisms are incompletely understood. Here we report that activation of polyamine catabolism promotes glutamine metabolism, leading to a targetable vulnerability in lung cancer.

    OEP005018

  • PROJ Single cell analysis of heterogeneity in acute promyelocytic leukemia

    Kankan Wang, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine,2023.01.03

    Description

    Single cell analysis of heterogeneity in acute promyelocytic leukemia

    OEP003829

  • PROJ Fungal community under different moisture content in Heshang Cave

    Hongmei Wang, China university of geosciences,2022.06.15

    Description

    OEP003447

  • PROJ Bacterial community under different moisture content in Heshang Cave

    Hongmei Wang, China university of geosciences,2022.06.15

    Description

    OEP003446

  • PROJ Shuangliu GDM

    Zheng Lab, Fudan univerisity,2022.07.03

    Description

    OEP003504

  • PROJ Bacterial communities in Panlong Cave, Guilin City

    Hongmei Wang, China university of geosciences,2021.01.08

    Description

    Bacterial community diversity in Panlong Cave, Guilin City, based on V3-V4 sequencing.

    OEP001480

  • PROJ Bacterial communities in Luohandu Cave, Guilin City

    Hongmei Wang, China university of geosciences,2021.01.08

    Description

    Bacterial community disversity in Luohandu Cave, based on V3-V4 sequencing.

    OEP001476

  • PROJ Bacterial communities in Xincuntun Cave, Guilin City

    Hongmei Wang, China university of geosciences,2021.01.06

    Description

    To address the issue, we collected different niches (such as, sediment, weathered rock, weathering crust, etc.) in a droughty cave located in Guilin City.

    OEP001459

  • PROJ Transcriptome analysis and m6A-meRIP-seq of CAFs in conjunctival melanoma

    Peiwei Chai, Shanghai Ninth people's hospital,2023.11.01

    Description

    OEP004688

  • PROJ ScRNA-seq of Conjunctival melanoma-validation cohort 1

    Peiwei Chai, Shanghai Ninth people's hospital,2024.01.22

    Description

    Conjunctival melanoma (CoM) is a devastating malignancy with unignorable potential to develop distant metastasis. Despite various therapeutic strategies for distant metastatic CoM, the clinical outcomes remain unfavorable. Herein, we performed single-cell transcriptomic profiling of 57,005 cells obtained from normal conjunctival samples (n=3), conjunctival melanoma (n=6) and lymph node metastasis (n=3). Notably, we noticed a higher abundance of cancer-associated fibroblasts (CAFs) in the tumor microenvironment, correlated with enhanced angiogenic capacity and increased VEGFR expression in distal metastatic CoM. Additionally, we observed a significant decrease in the number of CD8+ T cells and an increase in the proportion of CD8+ T naive cells, contributing to a relatively quiescent immunological environment in distal metastatic CoM. Given these key changes during CoM progression, we launched a clinical trial (ChiCTR2100045061) of VEGFR blockade combined with anti-PD1 therapy for distant metastatic CoM patients, which exhibited capable tumor-inhibitory efficacy. Conclusively, our study uncovered the landscape and heterogeneity of the tumor microenvironment (TME) during CoM tumorigenesis and progression, empowering clinical decisions in the management of distal metastatic CoM. To our knowledge, this is the initial exploration to translate single cell RNA-sequencing (scRNA-seq) analysis to a clinical trial dealing with cancer, providing a novel concept by accommodating scRNA-seq data in cancer therapy.

    OEP005011