DescriptionThe sediment sample is collected from the Mariana Trench slope in the western Pacific Ocean at the water depth of 8300 mbsl.
OEP003780
DescriptionWe transplanted gut microbiota from human donors with ASD or typically developing (TD) controls into antibiotic-treated mice. We analysed DNA methylation of specific target genes of both parental and offspring mice.
OEP005039
Description
OEP004782
Descriptionsamples in wetland of the Tibetan Plateau
OEP002737
DescriptionOur understanding of the underlying mechanisms for central nervous system metastasis (CNSm), including leptomeningeal metastasis (LM) and brain parenchymal metastasis (BM), is limited. To address this, we conducted single-cell RNA sequencing on 24 patients with CNSm to decipher and compare the tumor microenvironment (TME) of LM and BM. Our results reveal that the TME of LM is more immunosuppressive, characterized by reduced lymphocytes and an increased presence of SPP1+ myeloid cells compared to BM. Additionally, we observed TLS-like structures in a few BM samples, associated with a favorable response to TKI therapy. Furthermore, we explored the correlation between the endothelial cell subtype Endo2 and tumor volume in BM, and systematically compared blood-brain barrier (BBB) cells in CNSm to normal conditions, revealing significant phenotypic remodeling. These findings provide insights into the clinical differences between BM and LM and contribute to a better understanding and clinical treatment of CNSm.
OEP004944
DescriptionPolyamines play essential roles in both normal and cancer cell growth. Polyamine metabolism is frequently dysregulated and is considered as a therapeutic target in cancer. However, targeting polyamine metabolism as monotherapy often exhibits limited efficacy, and the underlying mechanisms are incompletely understood. Here we report that activation of polyamine catabolism promotes glutamine metabolism, leading to a targetable vulnerability in lung cancer.
OEP005018
DescriptionSingle cell analysis of heterogeneity in acute promyelocytic leukemia
OEP003829
Description
OEP003447
Description
OEP003446
Description
OEP003504