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  • PROJ Aommonia oxidizing archaea rather than amonia oxidizing bacteria played the key role in nitrification in alkaline oligotrophic subsurface karst cave

    Hongmei Wang, China university of geosciences,2023.12.01

    Description

    OEP004782

  • PROJ Microorganisms in wetlands of the Tibetan Plateau

    Jin Zeng, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences,2021.09.17

    Description

    samples in wetland of the Tibetan Plateau

    OEP002737

  • PROJ LC-CNSm

    shenbing shan, Lingang Laboratory,2024.01.03

    Description

    Our understanding of the underlying mechanisms for central nervous system metastasis (CNSm), including leptomeningeal metastasis (LM) and brain parenchymal metastasis (BM), is limited. To address this, we conducted single-cell RNA sequencing on 24 patients with CNSm to decipher and compare the tumor microenvironment (TME) of LM and BM. Our results reveal that the TME of LM is more immunosuppressive, characterized by reduced lymphocytes and an increased presence of SPP1+ myeloid cells compared to BM. Additionally, we observed TLS-like structures in a few BM samples, associated with a favorable response to TKI therapy. Furthermore, we explored the correlation between the endothelial cell subtype Endo2 and tumor volume in BM, and systematically compared blood-brain barrier (BBB) cells in CNSm to normal conditions, revealing significant phenotypic remodeling. These findings provide insights into the clinical differences between BM and LM and contribute to a better understanding and clinical treatment of CNSm.

    OEP004944

  • PROJ Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer

    Ning Wang, Shanghai Institute of Nutrition and Health, CAS,2024.01.24

    Description

    Polyamines play essential roles in both normal and cancer cell growth. Polyamine metabolism is frequently dysregulated and is considered as a therapeutic target in cancer. However, targeting polyamine metabolism as monotherapy often exhibits limited efficacy, and the underlying mechanisms are incompletely understood. Here we report that activation of polyamine catabolism promotes glutamine metabolism, leading to a targetable vulnerability in lung cancer.

    OEP005018

  • PROJ Single cell analysis of heterogeneity in acute promyelocytic leukemia

    Kankan Wang, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine,2023.01.03

    Description

    Single cell analysis of heterogeneity in acute promyelocytic leukemia

    OEP003829

  • PROJ Fungal community under different moisture content in Heshang Cave

    Hongmei Wang, China university of geosciences,2022.06.15

    Description

    OEP003447

  • PROJ Bacterial community under different moisture content in Heshang Cave

    Hongmei Wang, China university of geosciences,2022.06.15

    Description

    OEP003446

  • PROJ Shuangliu GDM

    Zheng Lab, Fudan univerisity,2022.07.03

    Description

    OEP003504

  • PROJ Bacterial communities in Panlong Cave, Guilin City

    Hongmei Wang, China university of geosciences,2021.01.08

    Description

    Bacterial community diversity in Panlong Cave, Guilin City, based on V3-V4 sequencing.

    OEP001480

  • PROJ Bacterial communities in Luohandu Cave, Guilin City

    Hongmei Wang, China university of geosciences,2021.01.08

    Description

    Bacterial community disversity in Luohandu Cave, based on V3-V4 sequencing.

    OEP001476