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  • PROJ Single cell profiles of ICC with GOLP treatment

    Guoming Shi, Zhongshan Hospital, Fudan University, Shanghai, 200032, China,2022.03.15

    Description

    Single-cell analysis deciphers the tumor microenvironment remodeling associated with response to GOLP treatment in intrahepatic cholangiocarcinoma

    OEP003206

  • PROJ POFUT1 promotes PDL1 stability to drive immune evasion and directs liver cancer to immunotherapy

    qianyu li, shanghaijiaotong university,2023.12.05

    Description

    OEP004799

  • PROJ Bacterial community of lake sediments in China

    Qinglong Wu, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences,2021.01.12

    Description

    IW（Inner Water)

    OEP001556

  • PROJ ten amoeba samples

    fei liu, SUN YAT-SEN UNIVERSITY,2023.12.06

    Description

    We used metagenomic techniques to measure 10 amoeba strains, focusing on the possible health risks of endophytes present in them

    OEP004802

  • PROJ Single-cell sequencing analysis of mouse lung tissue

    zhao ruolin, Zhejiang Chinese Medical University,2023.12.01

    Description

    OEP004779

  • PROJ m6A-seq

    wenting Xu, Zhejiang Chinese Medical University,2023.11.29

    Description

    OEP004775

  • PROJ CH0002

    Yixiang Shi, Accrete Covenant (AC) (Shanghai) Medical Technology Co., Ltd., Shanghai, China,2023.11.30

    Description

    OEP004778

  • PROJ CF DNA methylation of blood tissue

    Wenran Li, Chinese Academy of Sciences,2023.12.02

    Description

    This study analyzed two Chinese cohorts derived from a large Chinese population study, the Shanghai CF Study, composing of individuals consecutively enrolled from Shanghai CF Community, Shanghai from June 2009 to December 2012. Samples included Han Chinese individuals who were randomly sampled from the Shanghai CF study and generated genome-wide DNA methylation profiles in the whole blood tissue. Changes in DNA methylation reflect effects of environmental changes on the human genome and may help us to explain the link between obesity and environmental factors.

    OEP004784

  • PROJ Metagenomic Identification of Pathogens and Antimicrobial-Resistant Genes in Bacterial Positive Blood Cultures by Nanopore Sequencing

    Jie Chen, shanghai xuhui central hospital,2023.09.12

    Description

    OEP004528

  • PROJ Glycine deprivation induces DNA damage and thereby results in cell cycle arrest in myeloma cells

    Zhenhao Liu, Central South University,2021.01.08

    Description

    Exogenous glycine deprivation inhibits tumor progression in multiple myeloma (MM) both in vitro and in vivo. To explore the underlying mechanisms of glycine metabolisms in MM cells, RNA-sequencing was performed in ARP1 cells cultured in the absence or presence of glycine (10 mg/L) for 24 hours. Genes involving glycine metabolism, among which SLC6A9, GLDC, SHMT2, and GSS were significantly highly expressed. This finding indicated that exogenous glycine deprivation mainly affected glycine transport, glycine cleavage, the interconversion between glycine and serine, and glutathione synthesis. In addition, enrichment analysis of signaling pathways based on different genes showed half of top 10 enriched pathways were related to cell mitosis and DNA damage.

    OEP001473