Description
OEP004024
DescriptionWe collected pancreatic cancer samples by surgery palliative operation ascites or endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNA) and generated a PDPCOs cohort with whole-genome sequencing (WGS), RNA sequencing (RNA-seq), the assay for transposase-accessible chromatin using the sequencing (ATAC-seq), proteomics, phospho-proteomics, glyco-proteomics, drug sensitivities (targeted agents and chemotherapeutic drugs) and radiation sensitivity.
OEP004966
DescriptionCircular RNAs (circRNAs) are upregulated during neurogenesis. Where and how circRNAs are localized, and what roles they play during this process have remained elusive. By comparing the nuclear and cytoplasmic circRNAs between H9 cells and H9-derived forebrain neurons (FB), we found a subset of adenosine (A)-rich circRNAs are restricted in H9 nuclei but exported to cytosols upon forebrain neuron differentiation. This differentiation-coupled circRNA subcellular relocation is modulated by the poly(A)-binding protein PABPC1. In the nucleus, newly produced (A)-rich circRNAs are bound by PABPC1 and the nuclear basket protein TPR to prevent their nucleocytoplasmic export. Modulation of (A)-rich motifs in circRNAs remarkably alters their subcellular localization. Enforced (A)-rich circRNAs in cytosols result in mRNA translation suppression. Furthermore, decreased nuclear PABPC1 upon neuronal differentiation enables the export of (A)-rich circRNAs including circRTN4(2,3), which is required for neurite outgrowth. These findings uncover subcellular localization features of circRNAs, linking their processing and function during neurogenesis.
OEP005241
Description20240430_WGBS
OEP005253
Description
OEP005251
DescriptionThese are 16S rDNA sequences predicted from metagenomic reads, used for overall analysis of the prokaryotic community structure, diversity in aquatic environments, its relationship with seawater depth, and the variation of gene relative abundance with seawater depth.
OEP005246
Description20240428_WGS
OEP005243
DescriptionSummary statistics of "Genetic Loci Associated with Nail Plate Morphology in East Asian Populations"
OEP005227
DescriptionData for Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases
OEP005239
DescriptionMulti-omics study of p38-MAPK signaling in MASLD-Associated Hepatocellular Carcinoma and other etiologies
OEP005235