Chenxu Gao, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital,2023.04.11

Description

We report a prospective observational study enrolled 1,171 PDAC patients who had pancreatectomy. After substantive follow-up and proteomic profiling of 191 patient samples (referred to as 'PDAC_Proteomics'), we identified functional modules with clinical relevance, established a proteomic-level prognostic risk model for PDAC, and cross-validated the LASSO model using external as well as independent in-house cohorts. The 14 proteins in the established model were individually and independently quantified for each of 50 PDAC patients using parallel-reaction monitoring (PRM; see 'PDAC_PRM'). In addition, 185 out of 191 PDACs were subjected to RNA isolation after the dissection of formalin-fixed paraffin-embedding (FFPE) tumor tissues, followed by transcriptomic RNA-seq (see 'PDAC_Transcriptomic').

OEP004100

maoxiang xu, shanghai jiaotong university,2022.06.09

Description

OEP003436

Chenxu Gao, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital,2023.04.11

Description

OEP004098

Chenxu Gao, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital,2023.03.26

Description

A prospective observational study enrolled 1,171 PDAC patients who had pancreatectomy is reported. After substantive follow-up and proteomic profiling of 191 patient samples, we identify functional modules with clinical relevance, establish a proteomic-level prognostic risk model for PDAC, and cross-validate the model using external as well as independent in-house cohorts. Two new biomarkers, indicative of PDAC adjuvant chemotherapy sensitivity, are discovered using integrated analysis of both clinical and proteomic datasets. Our prospective evidence points us towards a subgroup of patients to whom mild adjuvant chemo plan (for example S-1) might provide overall survival benefit.

OEP004079

Yu Zhang, Shanghai Jiaotong University,2023.02.23

Description

The mock communities of MT-Enviro are expected to improve standardization and quality assurance of metatranscriptomic analysis for environmental microbes.

OEP003879

Yu He, China University of Geosciences (Wuhan),2023.07.19

Description

Viral communities in steel slag leachate

OEP004270

Bowei Han, Southern Medical University,2019.09.20

Description

To develop a noninvasive in vivo monitoring platform of the physiology and pathology of pregnancy, we merged whole-genome cfDNA sequencing data generated from non-invasive prenatal testing (NIPT), all the data is in aligned BAM format.

OEP000486

Cui-Cui Liu, ,2023.11.20

Description

Treatment of triple-negative breast cancer (TNBC) remains challenging. Cancer stem cells (CSCs) are the most intractable subpopulation of TNBC cells, which has associated with a high risk of relapse and poor prognosis. However, eradication of CSCs continues to be difficult. Here, we integrated the multiomics data of our large TNBC cohort (n=360) to identify vital markers of CSCs. We discovered that EMSY, inducing a BRCAness phenotype, was preferentially expressed in breast CSCs, promoted the enrichment of ALDH+ cells and was positively correlated with poor relapse-free survival. Mechanistically, EMSY competitively bound to the Jmjc domain, which was critical for the enzyme activity of the KDM5B-specific H3K4 demethylase to reshape methionine metabolism and promote CSC self-renewal and tumorigenesis in an H3K4 methylation-dependent manner. Moreover, EMSY accumulation in TNBC cells sensitized them to PARP inhibitors against bulk cells and methionine deprivation against CSCs. These findings indicate that clinically relevant eradication of CSCs could be achieved with a strategy that targets CSC-specific vulnerabilities in amino acid metabolism.

OEP004750

Xinjing Wang, Department of General Surgery, Pancreatic Disease Center,2023.11.19

Description

Here, we report two patients of advanced solid tumor both of whom achieved partial response after treated with combination therapy using an mRNA vaccine targeting KRAS G12V mutation and Pembrolizumab. Both patients were HLA-A11:01 subtype and their tumor harbors KRAS G12V mutation. Consistent with the clinical findings, both patients had a significant expansion of polyfunctional, KRAS G12V-specific CD8 cytotoxic T cells with high levels of INF-γ and TNF-α upon neoantigen stimulation.

OEP004748

GuLan chun, Fujun,2023.11.17

Description

OEP004747