OENC41474
Catalytic biopart
Map View
experimental evidence
Organism
Chassis
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HepG2 cell , Saccharomyces cerevisiae , yeast
Catalytic functions
External Links
EC number
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2.3.1.137 Carnitine O-octanoyltransferase.
Bioparts catalyze this reaction
| Biopart ID | Organisms | pH | temperature(ºC) | km |
|---|
2) (R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8-dimethylnonanoyl-(R)-carnitine
External Links
Bioparts catalyze this reaction
| Biopart ID | Organisms | pH | temperature(ºC) | km |
|---|
Organism
Taxonomy
Taxonomy ID
Organism
Lineage
cellular organisms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo;
Sequence and structure
Protein sequence
Protein ID
Sequence
TESTMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSAR静态页面数据
Protein family
definition
Nucleotide sequences (Optimized nucleotide sequences according to different chassises)
NT seq ID
Sequence
ASGSDGLJSLKJGOJSIDJIOJG静态数据
References
- N N A'Bháird; R R Ramsay; . 1992: Malonyl-CoA inhibition of peroxisomal carnitine octanoyltransferase. Biochemical Journal, 286 ( Pt 2) 637-40.
- K Lilly; G E Bugaisky; P K Umeda; L L Bieber; . 1990: The medium-chain carnitine acyltransferase activity associated with rat liver microsomes is malonyl-CoA sensitive. Archives of biochemistry and biophysics, 280 167-74.
- M J Healy; J Kerner; L L Bieber; . 1988: Enzymes of carnitine acylation. Is overt carnitine palmitoyltransferase of liver peroxisomal carnitine octanoyltransferase? Biochemical Journal, 249 231-7.
- S O Farrell; C J Fiol; J K Reddy; L L Bieber; . 1984: Properties of purified carnitine acyltransferases of mouse liver peroxisomes. The Journal of Biological Chemistry, 259 13089-95.
- S O Farrell; L L Bieber; . 1983: Carnitine octanoyltransferase of mouse liver peroxisomes: properties and effect of hypolipidemic drugs. Archives of biochemistry and biophysics, 222 123-32.
- C D Chung; L L Bieber; . 1993: Properties of the medium chain/long chain carnitine acyltransferase purified from rat liver microsomes. The Journal of Biological Chemistry, 268 4519-24.
- Y Pagot; J M Belin; . 1996: Involvement of carnitine acyltransferases in peroxisomal fatty acid metabolism by the yeast Pichia guilliermondii. Applied and Environmental Microbiology, 62 3864-7.
- C N Cronin; . 1997: cDNA cloning, recombinant expression, and site-directed mutagenesis of bovine liver carnitine octanoyltransferase--Arg505 binds the carboxylate group of carnitine. European Journal of Biochemistry, 247 1029-37.
- S Ferdinandusse; J Mulders; L IJlst; S Denis; G Dacremont; H R Waterham; R J Wanders; . 1999: Molecular cloning and expression of human carnitine octanoyltransferase: evidence for its role in the peroxisomal beta-oxidation of branched-chain fatty acids. Biochemical and Biophysical Research Communications, 263 213-8.
- C Caudevilla; D Serra; A Miliar; C Codony; G Asins; M Bach; F G Hegardt; . 1999: Processing of carnitine octanoyltransferase pre-mRNAs by cis and trans-splicing. Advances in experimental medicine and biology, 466 95-102.
- R R Ramsay; R D Gandour; . 1999: Selective modulation of carnitine long-chain acyltransferase activities. Kinetics, inhibitors, and active sites of COT and CPT-II. Advances in experimental medicine and biology, 466 103-9.
- F G Hegardt; M Bach; G Asins; C Caudevilla; M Morillas; C Codony; D Serra; . 2001: Post-transcriptional regulation of rat carnitine octanoyltransferase. Biochemical Society Transactions, 29 316-20.
- M Morillas; P Gómez-Puertas; R Roca; D Serra; G Asins; A Valencia; F G Hegardt; . 2001: Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity. The Journal of Biological Chemistry, 276 45001-8.
- Montserrat Morillas; Paulino Gómez-Puertas; Blanca Rubí; Josep Clotet; Joaquín Ariño; Alfonso Valencia; Fausto G Hegardt; Dolors Serra; Guillermina Asins; . 2002: Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain. The Journal of Biological Chemistry, 277 11473-80.
- Stephen W Scherer; Joseph Cheung; Jeffrey R MacDonald; Lucy R Osborne; Kazuhiko Nakabayashi; Jo-Anne Herbrick; Andrew R Carson; Layla Parker-Katiraee; Jennifer Skaug; Razi Khaja; Junjun Zhang; Alexander K Hudek; Martin Li; May Haddad; Gavin E Duggan; Bridget A Fernandez; Emiko Kanematsu; Simone Gentles; Constantine C Christopoulos; Sanaa Choufani; Dorota Kwasnicka; Xiangqun H Zheng; Zhongwu Lai; Deborah Nusskern; Qing Zhang; Zhiping Gu; Fu Lu; Susan Zeesman; Malgorzata J Nowaczyk; Ikuko Teshima; David Chitayat; Cheryl Shuman; Rosanna Weksberg; Elaine H Zackai; Theresa A Grebe; Sarah R Cox; Susan J Kirkpatrick; Nazneen Rahman; Jan M Friedman; Henry H Q Heng; Pier Giuseppe Pelicci; Francesco Lo-Coco; Elena Belloni; Lisa G Shaffer; Barbara Pober; Cynthia C Morton; James F Gusella; Gail A P Bruns; Bruce R Korf; Bradley J Quade; Azra H Ligon; Heather Ferguson; Anne W Higgins; Natalia T Leach; Steven R Herrick; Emmanuelle Lemyre; Chantal G Farra; Hyung-Goo Kim; Anne M Summers; Karen W Gripp; Wendy Roberts; Peter Szatmari; Elizabeth J T Winsor; Karl-Heinz Grzeschik; Ahmed Teebi; Berge A Minassian; Juha Kere; Lluis Armengol; Miguel Angel Pujana; Xavier Estivill; Michael D Wilson; Ben F Koop; Sabrina Tosi; Gudrun E Moore; Andrew P Boright; Eitan Zlotorynski; Batsheva Kerem; Peter M Kroisel; Erwin Petek; David G Oscier; Sarah J Mould; Hartmut Döhner; Konstanze Döhner; Johanna M Rommens; John B Vincent; J Craig Venter; Peter W Li; Richard J Mural; Mark D Adams; Lap-Chee Tsui; . 2003: Human chromosome 7: DNA sequence and biology. Science (New York, N.Y.), 300 767-72.
- Ladeana W Hillier; Robert S Fulton; Lucinda A Fulton; Tina A Graves; Kymberlie H Pepin; Caryn Wagner-McPherson; Dan Layman; Jason Maas; Sara Jaeger; Rebecca Walker; Kristine Wylie; Mandeep Sekhon; Michael C Becker; Michelle D O'Laughlin; Mark E Schaller; Ginger A Fewell; Kimberly D Delehaunty; Tracie L Miner; William E Nash; Matt Cordes; Hui Du; Hui Sun; Jennifer Edwards; Holland Bradshaw-Cordum; Johar Ali; Stephanie Andrews; Amber Isak; Andrew Vanbrunt; Christine Nguyen; Feiyu Du; Betty Lamar; Laura Courtney; Joelle Kalicki; Philip Ozersky; Lauren Bielicki; Kelsi Scott; Andrea Holmes; Richard Harkins; Anthony Harris; Cynthia Madsen Strong; Shunfang Hou; Chad Tomlinson; Sara Dauphin-Kohlberg; Amy Kozlowicz-Reilly; Shawn Leonard; Theresa Rohlfing; Susan M Rock; Aye-Mon Tin-Wollam; Amanda Abbott; Patrick Minx; Rachel Maupin; Catrina Strowmatt; Phil Latreille; Nancy Miller; Doug Johnson; Jennifer Murray; Jeffrey P Woessner; Michael C Wendl; Shiaw-Pyng Yang; Brian R Schultz; John W Wallis; John Spieth; Tamberlyn A Bieri; Joanne O Nelson; Nicolas Berkowicz; Patricia E Wohldmann; Lisa L Cook; Matthew T Hickenbotham; James Eldred; Donald Williams; Joseph A Bedell; Elaine R Mardis; Sandra W Clifton; Stephanie L Chissoe; Marco A Marra; Christopher Raymond; Eric Haugen; Will Gillett; Yang Zhou; Rose James; Karen Phelps; Shawn Iadanoto; Kerry Bubb; Elizabeth Simms; Ruth Levy; James Clendenning; Rajinder Kaul; W James Kent; Terrence S Furey; Robert A Baertsch; Michael R Brent; Evan Keibler; Paul Flicek; Peer Bork; Mikita Suyama; Jeffrey A Bailey; Matthew E Portnoy; David Torrents; Asif T Chinwalla; Warren R Gish; Sean R Eddy; John D McPherson; Maynard V Olson; Evan E Eichler; Eric D Green; Robert H Waterston; Richard K Wilson; . 2003: The DNA sequence of human chromosome 7. Nature, 424 157-64.
- Antonio G Cordente; Eduardo López-Viñas; María Irene Vázquez; Jan H Swiegers; Isak S Pretorius; Paulino Gómez-Puertas; Fausto G Hegardt; Guillermina Asins; Dolors Serra; . 2004: Redesign of carnitine acetyltransferase specificity by protein engineering. The Journal of Biological Chemistry, 279 33899-908.
- Daniela S Gerhard; Lukas Wagner; Elise A Feingold; Carolyn M Shenmen; Lynette H Grouse; Greg Schuler; Steven L Klein; Susan Old; Rebekah Rasooly; Peter Good; Mark Guyer; Allison M Peck; Jeffery G Derge; David Lipman; Francis S Collins; Wonhee Jang; Steven Sherry; Mike Feolo; Leonie Misquitta; Eduardo Lee; Kirill Rotmistrovsky; Susan F Greenhut; Carl F Schaefer; Kenneth Buetow; Tom I Bonner; David Haussler; Jim Kent; Mark Kiekhaus; Terry Furey; Michael Brent; Christa Prange; Kirsten Schreiber; Nicole Shapiro; Narayan K Bhat; Ralph F Hopkins; Florence Hsie; Tom Driscoll; M Bento Soares; Tom L Casavant; Todd E Scheetz; Michael J Brown-stein; Ted B Usdin; Shiraki Toshiyuki; Piero Carninci; Yulan Piao; Dawood B Dudekula; Minoru S H Ko; Koichi Kawakami; Yutaka Suzuki; Sumio Sugano; C E Gruber; M R Smith; Blake Simmons; Troy Moore; Richard Waterman; Stephen L Johnson; Yijun Ruan; Chia Lin Wei; S Mathavan; Preethi H Gunaratne; Jiaqian Wu; Angela M Garcia; Stephen W Hulyk; Edwin Fuh; Ye Yuan; Anna Sneed; Carla Kowis; Anne Hodgson; Donna M Muzny; John McPherson; Richard A Gibbs; Jessica Fahey; Erin Helton; Mark Ketteman; Anuradha Madan; Stephanie Rodrigues; Amy Sanchez; Michelle Whiting; Anup Madari; Alice C Young; Keith D Wetherby; Steven J Granite; Peggy N Kwong; Charles P Brinkley; Russell L Pearson; Gerard G Bouffard; Robert W Blakesly; Eric D Green; Mark C Dickson; Alex C Rodriguez; Jane Grimwood; Jeremy Schmutz; Richard M Myers; Yaron S N Butterfield; Malachi Griffith; Obi L Griffith; Martin I Krzywinski; Nancy Liao; Ryan Morin; Ryan Morrin; Diana Palmquist; Anca S Petrescu; Ursula Skalska; Duane E Smailus; Jeff M Stott; Angelique Schnerch; Jacqueline E Schein; Steven J M Jones; Robert A Holt; Agnes Baross; Marco A Marra; Sandra Clifton; Kathryn A Makowski; Stephanie Bosak; Joel Malek; ; . 2004: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research, 14 2121-7.
- M A K Westin; M C Hunt; S E H Alexson; . 2008: Short- and medium-chain carnitine acyltransferases and acyl-CoA thioesterases in mouse provide complementary systems for transport of beta-oxidation products out of peroxisomes. Cellular and Molecular Life Sciences, 65 982-90.
- Françoise Le Borgne; Amine Ben Mohamed; Morgan Logerot; Emilie Garnier; Jean Demarquoy; . 2011: Changes in carnitine octanoyltransferase activity induce alteration in fatty acid metabolism. Biochemical and Biophysical Research Communications, 409 699-704.
- Petra Van Damme; Marta Lasa; Bogdan Polevoda; Cristina Gazquez; Alberto Elosegui-Artola; Duk Soo Kim; Elena De Juan-Pardo; Kimberly Demeyer; Kristine Hole; Esther Larrea; Evy Timmerman; Jesus Prieto; Thomas Arnesen; Fred Sherman; Kris Gevaert; Rafael Aldabe; . 2012: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proceedings of the National Academy of Sciences of the United States of America, 109 12449-54.
Cross links
Brenda
Uniprot
Enzyme