OENC42182
Catalytic biopart
Map View
experimental evidence
Organism
Optimum pH
-
7.4 - 7.5
Optimum temperature(ºC)
-
Chassis
-
Escherichia coli strain BL21(DE3)
Catalytic functions
1) The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EC number
-
4.2.99.18 DNA-(apurinic or apyrimidinic site) lyase.
Bioparts catalyze this reaction
| Biopart ID | Organisms | pH | temperature(ºC) | km |
|---|
Qualitative and quantitative parameters:
pH
pH optimum
-
7.4 - 7.5
Organism
Taxonomy
Taxonomy ID
Organism
Lineage
cellular organisms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo;
Sequence and structure
Protein sequence
Protein ID
Sequence
TESTMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAHSAPKPSQASGKAHSAPKPSQASGAMEPRTGGAANPKGSRGSRGPSPLAGPSAR静态页面数据
Protein family
Protein structure
Nucleotide sequences (Optimized nucleotide sequences according to different chassises)
NT seq ID
Sequence
ASGSDGLJSLKJGOJSIDJIOJG静态数据
References
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- Maria Rogacheva; Alexander Ishchenko; Murat Saparbaev; Svetlana Kuznetsova; Vasily Ogryzko; . 2006: High resolution characterization of formamidopyrimidine-DNA glycosylase interaction with its substrate by chemical cross-linking and mass spectrometry using substrate analogs. The Journal of Biological Chemistry, 281 32353-65.
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- Anna Campalans; Rachel Amouroux; Anne Bravard; Bernd Epe; J Pablo Radicella; . 2007: UVA irradiation induces relocalisation of the DNA repair protein hOGG1 to nuclear speckles. Journal of Cell Science, 120 23-32.
- Monica Ropolo; Paolo Degan; Mara Foresta; Mariarosaria D'Errico; Denise Lasigliè; Eugenia Dogliotti; Gianluigi Casartelli; Simonetta Zupo; Alessandro Poggi; Guido Frosina; . 2007: Complementation of the oxidatively damaged DNA repair defect in Cockayne syndrome A and B cells by Escherichia coli formamidopyrimidine DNA glycosylase. Free radical biology & medicine, 42 1807-17.
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- Meltem Muftuoglu; Nadja C de Souza-Pinto; Arin Dogan; Maria Aamann; Tinna Stevnsner; Ivana Rybanska; Güldal Kirkali; Miral Dizdaroglu; Vilhelm A Bohr; . 2009: Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase. The Journal of Biological Chemistry, 284 9270-9.
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- Viktoriya S Sidorenko; Arthur P Grollman; Pawel Jaruga; Miral Dizdaroglu; Dmitry O Zharkov; . 2009: Substrate specificity and excision kinetics of natural polymorphic variants and phosphomimetic mutants of human 8-oxoguanine-DNA glycosylase. The FEBS journal, 276 5149-62.
- Vladimir V Koval; Nikita A Kuznetsov; Alexander A Ishchenko; Murat K Saparbaev; Olga S Fedorova; . 2010: Real-time studies of conformational dynamics of the repair enzyme E. coli formamidopyrimidine-DNA glycosylase and its DNA complexes during catalytic cycle. Mutation research, 685 3-10.
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- Pawel Jaruga; Yan Xiao; Vladimir Vartanian; R Stephen Lloyd; Miral Dizdaroglu; . 2010: Evidence for the involvement of DNA repair enzyme NEIL1 in nucleotide excision repair of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines. Biochemistry, 49 1053-5.
- Minmin Liu; Viswanath Bandaru; Jeffrey P Bond; Pawel Jaruga; Xiaobei Zhao; Plamen P Christov; Cynthia J Burrows; Carmelo J Rizzo; Miral Dizdaroglu; Susan S Wallace; . 2010: The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America, 107 4925-30.
- Brandy J Schalow; Charmain T Courcelle; Justin Courcelle; . 2011: Escherichia coli Fpg glycosylase is nonrendundant and required for the rapid global repair of oxidized purine and pyrimidine damage in vivo. Journal of Molecular Biology, 410 183-93.
- Stephanie L Ondovcik; Thomas J Preston; Gordon P McCallum; Peter G Wells; . 2013: Expression of human oxoguanine glycosylase 1 or formamidopyrimidine glycosylase in human embryonic kidney 293 cells exacerbates methylmercury toxicity in vitro. Toxicology and applied pharmacology, 271 41-8.
- Mara Foresta; Alberto Izzotti; Sebastiano La Maestra; Rosanna Micale; Alessandro Poggi; Donatella Vecchio; Guido Frosina; . 2014: Accelerated repair and reduced mutagenicity of DNA damage induced by cigarette smoke in human bronchial cells transfected with E.coli formamidopyrimidine DNA glycosylase. PLoS ONE, 9 e87984.
- Larissa Souza Arantes; Liliane Gonçalves Vila Nova; Bruno Carvalho Resende; Mainá Bitar; Ivan Evangelista Vale Coelho; Anderson Miyoshi; Vasco Ariston Azevedo; Luciana Lara Dos Santos; Carlos Renato Machado; Débora de Oliveira Lopes; . 2016: The Corynebacterium pseudotuberculosis genome contains two formamidopyrimidine-DNA glycosylase enzymes, only one of which recognizes and excises 8-oxoguanine lesion. Gene, 575 233-43.
- Rémy Le Meur; Françoise Culard; Virginie Nadan; Stéphane Goffinont; Franck Coste; Martine Guerin; Karine Loth; Céline Landon; Bertrand Castaing; . 2015: The nucleoid-associated protein HU enhances 8-oxoguanine base excision by the formamidopyrimidine-DNA glycosylase. Biochemical Journal, 471 13-23.
- Haoquan Li; Anton V Endutkin; Christina Bergonzo; Arthur J Campbell; Carlos de Los Santos; Arthur Grollman; Dmitry O Zharkov; Carlos Simmerling; . 2015: A dynamic checkpoint in oxidative lesion discrimination by formamidopyrimidine-DNA glycosylase. Nucleic Acids Research, 44 683-694.
- Anton V Endutkin; Simeon S Koptelov; Alexander V Popov; Natalya A Torgasheva; Alexander A Lomzov; Alphiya R Tsygankova; Tatiana V Skiba; Dmitry A Afonnikov; Dmitry O Zharkov; . 2018: Residue coevolution reveals functionally important intramolecular interactions in formamidopyrimidine-DNA glycosylase. DNA Repair, 69 24-33.
Cross links
Uniprot
Enzyme