Disorder "Obesity"
Found 54 records
Disorder information
Disorder name:
Obesity
Disoder ID:
OMIM entry:
Definition:
Accumulation of substantial excess body fat.
Modifier statisitcs
Record:
54
Gene:
25
Variant:
38
Reference:
9
Effect type:
Expressivity(54)
Modifier effect:
HDL-C and Triglyceride SNP*Tx Interaction association(11)
,Risk factor(9)
,1-Year log(TRIG) Change(5)
,Altered life span(5)
,1-Year HDL Change(4)
,Altered waist circumference(4)
,Altered waist-to-height ratio(3)
,Altered waist-to-hip ratio(3)
,Altered LDL(2)
,Altered indices of obesity(2)
,Altered obesity(2)
,Altered cholesterol(1)
,Altered hepatic triglyceride content(1)
,Altered severity(1)
,Baseline HDL Change(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| TSC1 | TSC1:c.2208+171A>G | Expressivity | Altered life span | HR=0.11, 95% CI: 0.03-0.47, P=0.003 | rs1063539 in ADIPOQ, rs11585329 in LEPR, and rs2519757 in TSC1 were associated with improved obesity, and breast cancer disease-free survival(DFS)more | more |
| PNPLA3 | PNPLA3:c.444C>G(p.Ile148Met) | Expressivity | Altered hepatic triglyceride content | Gene activity study | Previously, we showed that a missense mutation (I148M) in PNPLA3 (patatin-like phospholipase domain-containing 3 protein) is associated with increased hepatic triglyceride content in humans. The results of this study show that the amino acid substitution in PNPLA3 that confers susceptibility to nonalcoholic fatty liver disease (I148M) inhibits catalytic activity of the enzyme.more | more |
| PIK3CA | PIK3CA:c.-76-13274C>T | Expressivity | Altered life span | HR=1.50, 95% CI: 1.01-2.21, P=0.04 | rs1520220 in IGF1 and rs2677760 in PIK3CA were associated with worse obesity, and breast cancer disease-free survival(DFS).more | more |
| PGS1 | PGS1:rs4082919 | Expressivity | HDL-C and Triglyceride SNP*Tx Interaction association | P=0.0009 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more |
| PGS1:rs4082919 | Expressivity | 1-Year log(TRIG) Change | P=0.0048 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more | |
| LIPC | LIPC:rs1800588 | Expressivity | HDL-C and Triglyceride SNP*Tx Interaction association | P=0.0288 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more |
| LIPC:rs588136 | Expressivity | HDL-C and Triglyceride SNP*Tx Interaction association | P=0.0099 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more | |
| LIPC:rs588136 | Expressivity | 1-Year log(TRIG) Change | P=0.0106 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more | |
| LIPC:rs8034802 | Expressivity | HDL-C and Triglyceride SNP*Tx Interaction association | P=0.0061 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more | |
| LIPC:rs8034802 | Expressivity | 1-Year log(TRIG) Change | P=0.0406 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more |