Disorder "Obesity"
Found 54 records
Disorder information
Disorder name:
Obesity
Disoder ID:
OMIM entry:
Definition:
Accumulation of substantial excess body fat.
Modifier statisitcs
Record:
54
Gene:
25
Variant:
38
Reference:
9
Effect type:
Expressivity(54)
Modifier effect:
HDL-C and Triglyceride SNP*Tx Interaction association(11)
,Risk factor(9)
,1-Year log(TRIG) Change(5)
,Altered life span(5)
,1-Year HDL Change(4)
,Altered waist circumference(4)
,Altered waist-to-height ratio(3)
,Altered waist-to-hip ratio(3)
,Altered LDL(2)
,Altered indices of obesity(2)
,Altered obesity(2)
,Altered cholesterol(1)
,Altered hepatic triglyceride content(1)
,Altered severity(1)
,Baseline HDL Change(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| CETP | CETP:rs3764261 | Expressivity | Baseline HDL Change | P=2.5×10(-24) | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more |
| ARID1A | ARID1A:c.1138-14428T>C | Expressivity | Altered obesity | OR=1.22, P=3.72×10(-4) | Our study revealed significant associations of two variants rs6598860 and rs4589135 in ARID2A with overweight/obesity.more | more |
| ARID1A:n.-1062C>T | Expressivity | Altered obesity | OR=1.27, P=1.58×10(-4) | Our study revealed significant associations of two variants rs6598860 and rs4589135 in ARID1A with overweight/obesity.more | more | |
| APOB | APOB:rs693 | Expressivity | HDL-C and Triglyceride SNP*Tx Interaction association | P=0.0083 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more |
| APOB:rs693 | Expressivity | 1-Year log(TRIG) Change | P=0.0111 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more | |
| AFF1 | AFF1:rs3775214 | Expressivity | 1-Year log(TRIG) Change | P=0.0141 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more |
| AFF1:rs3775214 | Expressivity | HDL-C and Triglyceride SNP*Tx Interaction association | P=0.0177 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more | |
| ADRB3 | ADRB3:c.190T>C(p.Trp64Arg) | Expressivity | Risk factor | From review article | Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more | more |
| ADRB2 | ADRB2:c.46A>G(p.Arg16Gly) | Expressivity | Risk factor | From review article | Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more | more |
| ADRB2:c.79C>G(p.Gln27Glu) | Expressivity | Risk factor | From review article | Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more | more |