Disorder "Obesity"
Found 54 records
Disorder information
Disorder name:
Obesity
Disoder ID:
OMIM entry:
Definition:
Accumulation of substantial excess body fat.
Modifier statisitcs
Record:
54
Gene:
25
Variant:
38
Reference:
9
Effect type:
Expressivity(54)
Modifier effect:
HDL-C and Triglyceride SNP*Tx Interaction association(11)
,Risk factor(9)
,1-Year log(TRIG) Change(5)
,Altered life span(5)
,1-Year HDL Change(4)
,Altered waist circumference(4)
,Altered waist-to-height ratio(3)
,Altered waist-to-hip ratio(3)
,Altered LDL(2)
,Altered indices of obesity(2)
,Altered obesity(2)
,Altered cholesterol(1)
,Altered hepatic triglyceride content(1)
,Altered severity(1)
,Baseline HDL Change(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| Haplotype | Haplotype:(UCP2-UCP3:rs659366,rs653529,rs15763,rs1726745:AGAG) | Expressivity | Altered waist-to-hip ratio | P=0.05 | AGAG haplotype is associated with decreased waist-to-hip ratiomore | more |
| GLI1 | GLI1:c.820G>C(p.Gly274Arg) | Expressivity | Altered severity | Assessment of genotype–phenotype associations | The variant in GLI1 possibly exacerbates disease severity when in the homozygous state.more | more |
| FADS2 | FADS2:rs1535 | Expressivity | 1-Year HDL Change | P=0.0037 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more |
| FADS2:rs1535 | Expressivity | HDL-C and Triglyceride SNP*Tx Interaction association | P=0.0352 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more | |
| FADS1 | FADS1:rs174548 | Expressivity | 1-Year HDL Change | P=0.0132 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more |
| FADS1:rs174548 | Expressivity | HDL-C and Triglyceride SNP*Tx Interaction association | P=0.0295 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more | |
| CPT1B | CPT1B:rs131759 | Expressivity | Altered indices of obesity | P=0.008 | Indices of obesity might be modulated by an interaction between CPT1 variants and fat intakemore | more |
| CPT1B:rs470117 | Expressivity | Altered indices of obesity | P=0.05 | Indices of obesity might be modulated by an interaction between CPT1 variants and fat intakemore | more | |
| CETP | CETP:rs3764261 | Expressivity | 1-Year HDL Change | P=0.0038 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more |
| CETP:rs3764261 | Expressivity | HDL-C and Triglyceride SNP*Tx Interaction association | P=0.0471 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more |