Disorder "Hypertension"
Found 10 records
Disorder information
Disorder name:
Hypertension 
Disoder ID:
Synonyms:
HTN,High blood pressure,hyperpiesia,vascular hypertensive disorder,hypertensive disease 
Definition:
The presence of chronic increased pressure in the systemic arterial system. 
Modifier statisitcs
Record:
10 
Gene:
Variant:
Reference:
Effect type:
Expressivity(10)  
Modifier effect:
Risk factor(6) ,Affect the likelihood of hypertension(1) ,Altered blood pressure and RAAS responses to the DASH diet(1) ,Altered relation between body size and BP(1) ,Altered systolic BP(1)  
Modifier gene Variant Effect type Modifier effect Evidence Effect PubMed ID
CYP4A11 CYP4A11:c.T8590C Expressivity  Altered systolic BP  P=0.04  Men with the 8590CC genotype had significantly higher systolic BPmore more
CHRNA3 CHRNA3:c.377+1710A>G Expressivity  Affect the likelihood of hypertension  P<0.05  CHRNA3 rs6495308 genotype was found to affect the likelihood of hypertension in Chinese male smokers.more more
AGT AGT:c.-20A>C Expressivity  Altered relation between body size and BP  N = 399, r = 0.23, P<0.0001  AGT gene promoter region variant is an important modifier of the relation between body size and BP,corroborate the notion that genetic modifiers can produce a profound impact on BP-phenotypic relations.more more
ADRB3 ADRB3:c.190T>C(p.Trp64Arg) Expressivity  Risk factor  From review article  Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more more
ADRB2 ADRB2:c.46A>G(p.Arg16Gly) Expressivity  Altered blood pressure and RAAS responses to the DASH diet  P=0.03  There is an association between the G46A polymorphism of beta2-AR and blood pressure and RAAS responses to the DASH diet, which suggests that beta2-AR may be a genetic modifier of DASH-diet responsiveness.more more
ADRB2:c.46A>G(p.Arg16Gly) Expressivity  Risk factor  From review article  Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more more
ADRB2:c.79C>G(p.Gln27Glu) Expressivity  Risk factor  From review article  Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more more
ADRB2:T164I Expressivity  Risk factor  From review article  Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more more
ADRB1 ADRB1:c.145A>G(p.Ser49Gly) Expressivity  Risk factor  From review article  Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more more
ADRB1:c.1165G>C(p.Gly389Arg) Expressivity  Risk factor  From review article  Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more more
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