Disorder "Hypertension"
Found 10 records
Disorder information
Disorder name:
Hypertension
Disoder ID:
Synonyms:
HTN,High blood pressure,hyperpiesia,vascular hypertensive disorder,hypertensive disease
Definition:
The presence of chronic increased pressure in the systemic arterial system.
Modifier statisitcs
Record:
10
Gene:
6
Variant:
9
Reference:
5
Effect type:
Expressivity(10)
Modifier effect:
Risk factor(6)
,Affect the likelihood of hypertension(1)
,Altered blood pressure and RAAS responses to the DASH diet(1)
,Altered relation between body size and BP(1)
,Altered systolic BP(1)
Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
---|---|---|---|---|---|---|
CYP4A11 | CYP4A11:c.T8590C | Expressivity | Altered systolic BP | P=0.04 | Men with the 8590CC genotype had significantly higher systolic BPmore | more |
CHRNA3 | CHRNA3:c.377+1710A>G | Expressivity | Affect the likelihood of hypertension | P<0.05 | CHRNA3 rs6495308 genotype was found to affect the likelihood of hypertension in Chinese male smokers.more | more |
AGT | AGT:c.-20A>C | Expressivity | Altered relation between body size and BP | N = 399, r = 0.23, P<0.0001 | AGT gene promoter region variant is an important modifier of the relation between body size and BP,corroborate the notion that genetic modifiers can produce a profound impact on BP-phenotypic relations.more | more |
ADRB3 | ADRB3:c.190T>C(p.Trp64Arg) | Expressivity | Risk factor | From review article | Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more | more |
ADRB2 | ADRB2:c.46A>G(p.Arg16Gly) | Expressivity | Altered blood pressure and RAAS responses to the DASH diet | P=0.03 | There is an association between the G46A polymorphism of beta2-AR and blood pressure and RAAS responses to the DASH diet, which suggests that beta2-AR may be a genetic modifier of DASH-diet responsiveness.more | more |
ADRB2:c.46A>G(p.Arg16Gly) | Expressivity | Risk factor | From review article | Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more | more | |
ADRB2:c.79C>G(p.Gln27Glu) | Expressivity | Risk factor | From review article | Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more | more | |
ADRB2:T164I | Expressivity | Risk factor | From review article | Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more | more | |
ADRB1 | ADRB1:c.145A>G(p.Ser49Gly) | Expressivity | Risk factor | From review article | Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more | more |
ADRB1:c.1165G>C(p.Gly389Arg) | Expressivity | Risk factor | From review article | Although βAR SNPs may not directly cause disease, they appear to be risk factors for, and modifiers of, disease and the response to stress and drugs.more | more |
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