Variant "AGT:c.-20A>C"
Search result: 1 record
Variant information
Gene:
AGT 
Variant:
AGT:c.-20A>C 
dbSNP ID:
no data 
GWAS trait:
no data 
Modifier statisitcs
Record:
1 
Disorder:
1 
Reference:
1 
Effect type:
Expressivity(1)  
Modifier effect:
Altered relation between body size and BP(1)  
Detail：
  • Target disease:
    Hypertension (DOID_10763)
    Effect type:
    Expressivity 
    Modifier effect:
    Altered relation between body size and BP 
    Evidence:
    N = 399, r = 0.23, P<0.0001 
    Effect:
    AGT gene promoter region variant is an important modifier of the relation between body size and BP，corroborate the notion that genetic modifiers can produce a profound impact on BP-phenotypic relations.
    Reference:
    PMID12234952
    Title:
    Angiotensinogen gene promoter region variant modifies body size-ambulatory blood pressure relations in hypertension.
    Species studied:
    Human
    Abstract:
    The extent to which genes modify the relationship between risk factors for hypertension and blood pressure (BP) is unclear. As angiotensinogen is expressed in adipose tissue and angiotensinogen (AGT) gene promoter variants influence the production of angiotensinogen, we evaluated the role of AGT gene variants as potential modifiers of body size-BP relations.