Disorder "Necrosis"
Found 35 records
Disorder information
Disorder name:
Necrosis
Disoder ID:
Synonyms:
tissue necrosis
Definition:
A disease where there is cellular death (necrosis) of bone components due to interruption of the blood supply.
Modifier statisitcs
Record:
35
Gene:
10
Variant:
35
Reference:
1
Effect type:
Expressivity(35)
Modifier effect:
Risk factor(35)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| TGFBR3 | TGFBR3:c.62-8892G>A | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more |
| TGFBR2 | TGFBR2:c.529+4864T>C | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more |
| TGFBR2:c.530-5386G>A | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more | |
| STARD13 | STARD13:c.*2635C>T | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more |
| STARD13:c.3225-197A>G | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more | |
| STARD13:n.33667465G>A | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more | |
| PDS5B | PDS5B:hcv11710292 | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more |
| PDS5B:hcv3118898 | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more | |
| KL | KL:c.1331-195A>G | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more |
| KL:c.819+15922G>T | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more |