Disorder "Necrosis"
Found 35 records
Disorder information
Disorder name:
Necrosis
Disoder ID:
Synonyms:
tissue necrosis
Definition:
A disease where there is cellular death (necrosis) of bone components due to interruption of the blood supply.
Modifier statisitcs
Record:
35
Gene:
10
Variant:
35
Reference:
1
Effect type:
Expressivity(35)
Modifier effect:
Risk factor(35)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| ERG | ERG:c.40-32009A>C | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more |
| EDN1 | EDN1:c.318A>G(p.Glu106Glu) | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more |
| EDN1:hcv7464888 | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more | |
| ECE1 | ECE1:c.762+172G>A | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more |
| BMP6 | BMP6:c.*5958T>G | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more |
| BMP6:c.1205-6955C>T | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more | |
| BMP6:c.664+41000G>C | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more | |
| BMP6:c.857+3770T>A | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more | |
| BMP6:c.857+8026A>G | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more | |
| ANXA2 | ANXA2:c.1015-340G>A | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more |