Disorder "Necrosis"
Found 35 records
Disorder information
Disorder name:
Necrosis
Disoder ID:
Synonyms:
tissue necrosis
Definition:
A disease where there is cellular death (necrosis) of bone components due to interruption of the blood supply.
Modifier statisitcs
Record:
35
Gene:
10
Variant:
35
Reference:
1
Effect type:
Expressivity(35)
Modifier effect:
Risk factor(35)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| KL | KL:c.819+1703C>A | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more |
| KL:c.819+2759A>G | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more | |
| KL:c.819+3284C>T | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more | |
| KL:c.819+3731G>A | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more | |
| KL:c.819+3803T>G | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more | |
| KL:c.819+4792A>G | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more | |
| KL:c.819+8262A>G | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more | |
| KL:c.819+8880T>C | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more | |
| KL:c.820-14772G>A | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more | |
| ERG | ERG:c.258-2281G>T | Expressivity | Risk factor | Assessment of genotype–phenotype associations | Bone morphogenic protein 6, annexin A2, and klotho were associated with sickle cell osteonecrosis and at high risk for osteonecrosis.more | more |