Disorder "Ovarian Cancer"
Found 265 records
Disorder information
Disorder name:
Ovarian Cancer
Disoder ID:
OMIM entry:
Synonyms:
malignant tumour of ovary, tumor of the Ovary, ovarian neoplasm, primary ovarian cancer, malignant Ovarian tumor, ovary neoplasm
Definition:
A tumor (abnormal growth of tissue) of the ovary.
Modifier statisitcs
Record:
265
Gene:
16
Variant:
252
Reference:
12
Effect type:
Expressivity(265)
Modifier effect:
Risk factor(252)
,Altered onset time(10)
,Expressivity(2)
,Altered susceptibility(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| TP73 | TP73:n.*4203C>T | Expressivity | Altered susceptibility | OR=1.55; 95% CI:1.07-2.19; P=0.003 | The p73 rs6695978 G>A polymorphism will serve as a modifier of ovarian cancer susceptibility and prognosis.more | more |
| TP53 | TP53:rs1042522 | Expressivity | Risk factor | OR=8.7, 95 % CI: 1.66-45.48 | That polymorphism of BAX and TP53 genes may be potential genetic modifiers for developing ovarian cancer.more | more |
| SLC4A7 | SLC4A7:c.*2242G>A | Expressivity | Risk factor | From review article | Genetic modifiers of breast and ovarian cancer riskmore | more |
| RAD51 | RAD51:c.135G>C | Expressivity | Risk factor | OR=0.38; 95% CI: 0.18-0.82 | These findings suggest that the effect of the RAD51 C allele is an important risk modifier for malignancies occurring on a background of BRCA1 mutations.more | more |
| RAD51:c.135G>C | Expressivity | Risk factor | P<0.05 | We have identified a RAD51 5' untranslated region SNP that may be associated with an increased risk of breast cancer and a lower risk of ovarian cancer among BRCA2 mutation carriersmore | more | |
| OGG1 | OGG1:c.*2246G>A | Expressivity | Risk factor | P=0.023 | rs2304277 variant in the OGG1 glycosidase gene of the Base Excision Repair pathway can increase ovarian cancer risk in BRCA1 mutation carriers.more | more |
| MDM2 | MDM2:n.-3306A>C | Expressivity | Risk factor | OR=3.93; 95% CI: 1.41-10.90, P=0.009 | MDM2 SNP309 acts as a modifier of mutant BRCA1/2 mutant alleles in AJ and may accelerate breast and ovarian carcinogenesis in genetically predisposed individuals.more | more |
| MAP3K1 | MAP3K1:n.56031884C>A | Expressivity | Risk factor | From review article | Genetic modifiers of breast and ovarian cancer riskmore | more |
| LSP1 | LSP1:c.*13+200T>C | Expressivity | Risk factor | From review article | Genetic modifiers of breast and ovarian cancer riskmore | more |
| LOC101928278 | LOC101928278:n.217905832A>G | Expressivity | Altered onset time | Assessment of genotype–phenotype associations | Ten variants were found to be significantly associated with early onset cancermore | more |