Gene "TP73"
Found 1 record
Gene information
Gene symbol:
TP73
See related:
Ensembl: ENSG00000078900, Gene ID: 7161
Additive variants :
Undetected
Genetic interaction partners
No data
Modifier statisitcs
Record:
1 
Disorder:
1 
Vriant:
1 
Reference:
1 
Effect type:
Expressivity(1)  
Modifier effect:
Altered susceptibility(1)  
Detail：
  • Variant 1:
    TP73:n.*4203C>T
    Gene:
    TP73
    Genomic location:
    chr1:3648345
    dbSNP ID:
    rs6695978
    Target disease:
    Ovarian Cancer(DOID_2394)
    Effect type:
    Expressivity 
    Modifier effect:
    Altered susceptibility 
    Evidence:
    OR=1.55; 95% CI:1.07-2.19; P=0.003 
    Effect:
    The p73 rs6695978 G>A polymorphism will serve as a modifier of ovarian cancer susceptibility and prognosis.
    Reference:
    PMID23095717
    Title:
    Polymorphisms in the p63 and p73 genes are associated with ovarian cancer risk and clinicopathological variables.
    Species studied:
    Human
    Abstract:
    p73 and p63 are two structural and functional homologs of p53, and their biological functions in cancer progression have attracted attention due to the presence of variants generated by genetic polymorphisms. Recently, three single nucleotide polymorphisms (SNPs) in the p63 and p73 genes have been associated with female reproduction. In the present study, we aimed to evaluate the relationship between these SNPs and ovarian cancer susceptibility and clinical pathology.