Gene "IL17RA"
Found 1 record
Gene information
Gene symbol:
IL17RA
See related:
Ensembl: ENSG00000177663, Gene ID: 23765
Additive variants :
Undetected
Genetic interaction partners
No data
Modifier statisitcs
Record:
1 
Disorder:
1 
Vriant:
1 
Reference:
1 
Effect type:
Expressivity(1)  
Modifier effect:
Altered severity(1)  
Detail：
  • Variant 1:
    IL17RA:rs4819554
    Gene:
    IL17RA
    Genomic location:
    dbSNP ID:
    rs4819554
    Target disease:
    Psoriasiform Dermatitis(HP:0003765)
    Effect type:
    Expressivity 
    Modifier effect:
    Altered severity 
    Evidence:
    OR=1.33, 95% CI:1.05-1.69; p=0.017 
    Effect:
    We identified the IL17RA rs4819554 SNP as a risk factor for PsO. The IL17E rs79877597 SNP was a modifier of the risk for PsO disease severity and PsA.
    Reference:
    PMID26347322
    Title:
    Association between single nucleotide polymorphisms IL17RA rs4819554 and IL17E rs79877597 and Psoriasis in a Spanish cohort.
    Species studied:
    Human
    Abstract:
    The IL17 pathway plays an important role in the pathogenesis of psoriasis (PsO).