Disorder "Type 2 Diabetes Mellitus"
Found 50 records
Disorder information
Disorder name:
Type 2 Diabetes Mellitus
Disoder ID:
OMIM entry:
Synonyms:
non-insulin-dependent diabetes mellitus, type II diabetes mellitus, NIDDM
Definition:
A type of diabetes mellitus initially characterized by insulin resistance and hyperinsulinemia and subsequently by glucose interolerance and hyperglycemia.
Modifier statisitcs
Record:
50
Gene:
18
Variant:
36
Reference:
14
Effect type:
Expressivity(39)
,Penetrance(11)
Modifier effect:
Altered incidence(11)
,HDL-C and Triglyceride SNP*Tx Interaction association(11)
,Risk factor(9)
,Altered level of glycaemia(6)
,1-Year log(TRIG) Change(5)
,1-Year HDL Change(4)
,Altered susceptibility(3)
,Baseline HDL Change(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| SCL30A8 | SCL30A8:c.271+G>A | Penetrance | Altered incidence | Combined OR=0.34, 95% CI: (0.21–0.53), P=1.7×10(-6) | SLC30A8 haploinsufficiency protects against T2Dmore | more |
| SCL30A8:c.419-1G>C | Penetrance | Altered incidence | Combined OR=0.34, 95% CI: (0.21–0.53), P=1.7×10(-6) | SLC30A8 haploinsufficiency protects against T2Dmore | more | |
| SCL30A8:c.572+1G>A | Penetrance | Altered incidence | Combined OR=0.34, 95% CI: (0.21–0.53), P=1.7×10(-6) | SLC30A8 haploinsufficiency protects against T2Dmore | more | |
| SCL30A8:c.71+2T>A | Penetrance | Altered incidence | Combined OR=0.34, 95% CI: (0.21–0.53), P=1.7×10(-6) | SLC30A8 haploinsufficiency protects against T2Dmore | more | |
| SCL30A8:p.Arg138* | Penetrance | Altered incidence | P=0.0067, OR=0.47, 95% CI: (0.27–0.81) | SLC30A8 haploinsufficiency protects against T2Dmore | more | |
| SCL30A8:p.Gln174* | Penetrance | Altered incidence | Combined OR=0.34, 95% CI: (0.21–0.53), P=1.7×10(-6) | SLC30A8 haploinsufficiency protects against T2Dmore | more | |
| SCL30A8:p.Ile291Phefs*2 | Penetrance | Altered incidence | P=0.0021, OR=0.30, 95% CI: (0.14–0.64) | SLC30A8 haploinsufficiency protects against T2Dmore | more | |
| SCL30A8:p.Lys34Serfs*50 | Penetrance | Altered incidence | P=0.0019, OR=0.17, 95% CI: (0.05–0.52) | SLC30A8 haploinsufficiency protects against T2Dmore | more | |
| SCL30A8:p.Ser327Thrs*55 | Penetrance | Altered incidence | Combined OR=0.34, 95% CI: (0.21–0.53), P=1.7×10(-6) | SLC30A8 haploinsufficiency protects against T2Dmore | more | |
| SCL30A8:p.Trp152* | Penetrance | Altered incidence | Combined OR=0.34, 95% CI: (0.21–0.53), P=1.7×10(-6) | SLC30A8 haploinsufficiency protects against T2Dmore | more |