Disorder "Type 2 Diabetes Mellitus"
Found 50 records
Disorder information
Disorder name:
Type 2 Diabetes Mellitus
Disoder ID:
OMIM entry:
Synonyms:
non-insulin-dependent diabetes mellitus, type II diabetes mellitus, NIDDM
Definition:
A type of diabetes mellitus initially characterized by insulin resistance and hyperinsulinemia and subsequently by glucose interolerance and hyperglycemia.
Modifier statisitcs
Record:
50
Gene:
18
Variant:
36
Reference:
14
Effect type:
Expressivity(39)
,Penetrance(11)
Modifier effect:
Altered incidence(11)
,HDL-C and Triglyceride SNP*Tx Interaction association(11)
,Risk factor(9)
,Altered level of glycaemia(6)
,1-Year log(TRIG) Change(5)
,1-Year HDL Change(4)
,Altered susceptibility(3)
,Baseline HDL Change(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| LIPC | LIPC:rs588136 | Expressivity | HDL-C and Triglyceride SNP*Tx Interaction association | P=0.0099 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more |
| LIPC:rs588136 | Expressivity | 1-Year log(TRIG) Change | P=0.0106 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more | |
| LIPC:rs8034802 | Expressivity | HDL-C and Triglyceride SNP*Tx Interaction association | P=0.0061 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more | |
| LIPC:rs8034802 | Expressivity | 1-Year log(TRIG) Change | P=0.0406 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more | |
| LILRA3 | LILRA3:rs103294 | Expressivity | 1-Year HDL Change | P=0.0349 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more |
| LILRA3:rs103294 | Expressivity | HDL-C and Triglyceride SNP*Tx Interaction association | P=0.0472 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more | |
| IRS2 | IRS2:c.3170G>A(p.Gly1057Asp) | Expressivity | Risk factor | Assessment of genotype–phenotype associations | This meta-analysis suggested that D allele of G1057D polymorphism have a significant effect on reduced risk of T2DM, and obesity is a modifier of this association.more | more |
| IL6 | IL6:c.-174C>G | Expressivity | Risk factor | 17.68-fold (95% CI: 3.57- to 87.66-fold) | The CC genotype showed a more than 5-fold increased risk of developing T2DM compared with the remaining genotypesmore | more |
| FADS2 | FADS2:rs1535 | Expressivity | 1-Year HDL Change | P=0.0037 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more |
| FADS2:rs1535 | Expressivity | HDL-C and Triglyceride SNP*Tx Interaction association | P=0.0352 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more |