Gene "ABCG2"
Found 1 record
Gene information
Gene symbol:
ABCG2
See related:
Ensembl: ENSG00000118777, Gene ID: 9429
Additive variants :
Detected
Genetic interaction partners
No data
Modifier statisitcs
Record:
1 
Disorder:
1 
Vriant:
1 
Reference:
1 
Effect type:
Expressivity(1)  
Modifier effect:
Risk factor and Altered life span(1)  
Detail：
  • Variant 1:
    ABCG2:c.1738-46G>A
    Gene:
    ABCG2
    Genomic location:
    chr4:89015857
    dbSNP ID:
    rs2231164
    Target disease:
    Pancreatic Cancer(DOID_1793)
    Effect type:
    Expressivity 
    Modifier effect:
    Risk factor and Altered life span 
    Evidence:
    P=0.0023 
    Effect:
    Significant associations between mutation and overall survival in pancreatic cancer, as well as survival interactions between various genes and radiotherapy and chemotherapy.
    Reference:
    PMID21487324
    Title:
    Genetic effects and modifiers of radiotherapy and chemotherapy on survival in pancreatic cancer.
    Species studied:
    Human
    Abstract:
    Germ-line genetic variation may affect clinical outcomes of cancer patients. We applied a candidate-gene approach to evaluate the effect of putative markers on survival of patients with pancreatic cancer. We also examined gene-radiotherapy and gene-chemotherapy interactions, aiming to explain interindividual differences in treatment outcomes.