PhenoModifier-Gene Detail

Gene "DPYD"

Found 1 record

Gene information

Gene symbol:

DPYD

See related:

Ensembl: ENSG00000188641, Gene ID: 1806

Additive variants :

Detected

Genetic interaction partners

Confidence	Stringent (ε>0.16 or ε<-0.12)	Intermediate (-0.16≤ε≤-0.08 or 0.08≤ε≤0.16)	Lenient (\|ε\|<0.08)
Positive interactions	RPS10 PTRH1 BBOX1 NAA30 EEF1G DUS4L ATAD2 MOV10 SCP2 RPS23 MRS2 DNM1L REXO5 PBLD PSPH MAPKAPK5 NKTR CCDC25 SLC26A11 VPS13D FAAH GAPDH RPL36 HAGHL MRI1 DPH5 SH3YL1 CLUH SNX8 RTN4IP1 DBR1 MBOAT4 GLO1 RRM1 ABAT TUBA3D SOD2 GPX7 BRSK1 RPL7A EEF1G CAMKK2 RAB5B PPAN OSBPL10 IMPDH1 HORMAD1 CYB5B CHPT1 ANKRD55 DPH2 TRIT1 PGAP1 DDX31 APIP HDAC7 ETFA PTPA NOLC1 LIG4 PNP DPYSL2 ALLC show allhide
Negative interactions	NAPEPLD COX10 LIAS VAT1L ACAA1 MAP3K2 LIPT2 BUD31 SLC25A32 RAB5B BCS1L ACP1 UBE2V2 RPEL1 CHN1 HIPK2 BIN3 TRMT44 FASN IMPACT COQ7 LIPT1 IDH3B DDX21 HEMK1 EXO1 RAD52 ATIC RCE1 AP2M1 AHI1 PFAS ENPP2 ERMP1 TGIF2 CAMKK2 TUSC3 LSM1 PGD PLAA TM9SF3 TRNAU1AP RANGRF BMP2K DBI TMEM87A show allhide

Modifier statisitcs

Record:

Disorder:

Vriant:

Reference:

Effect type:

Expressivity(1)

Modifier effect:

Risk factor and Altered life span(1)

Detail：

Variant 1:

DPYD:c.2623-38806T>C

Gene:

DPYD

Genomic location:

chr1:97602994

dbSNP ID:

rs1760217

Target disease:

Pancreatic Cancer(DOID_1793)

Effect type:

Expressivity

Modifier effect:

Risk factor and Altered life span

Evidence:

P=0.0013

Effect:

Significant associations between mutation and overall survival in pancreatic cancer, as well as survival interactions between various genes and radiotherapy and chemotherapy.

Reference:

PMID21487324

Title:

Genetic effects and modifiers of radiotherapy and chemotherapy on survival in pancreatic cancer.

Species studied:

Human

Abstract:

Germ-line genetic variation may affect clinical outcomes of cancer patients. We applied a candidate-gene approach to evaluate the effect of putative markers on survival of patients with pancreatic cancer. We also examined gene-radiotherapy and gene-chemotherapy interactions, aiming to explain interindividual differences in treatment outcomes.