Gene "IRX3"
Found 2 records
Gene information
Gene symbol:
IRX3
See related:
Ensembl: ENSG00000177508, Gene ID: 79191
Additive variants :
Undetected
Genetic interaction partners
No data
Modifier statisitcs
Record:
2 
Disorder:
1 
Vriant:
2 
Reference:
1 
Effect type:
Expressivity(2)  
Modifier effect:
Risk factor(2)  
Details：
  • Variant 1:
    IRX3:c.1437G>T(p.Gln479His)
    Gene:
    IRX3
    Genomic location:
    chr16:54318172
    dbSNP ID:
    rs1126960
    Target disease:
    Obesity(DOID_9970)
    Effect type:
    Expressivity 
    Modifier effect:
    Risk factor 
    Evidence:
    P=0.747 
    Effect:
    The rs8053360 CC and rs1126960 GG genotypes were associated with increased birth weight and BMI, especially in females.
    Reference:
    PMID28316138
    Title:
    IRX3 is a genetic modifier for birth weight, adolescent obesity and transaminase metabolism.
    Species studied:
    Human
    Abstract:
    IRX3 expression has been functionally associated in obesity-associated long-distance susceptibility loci, but the effect of the IRX3 genetic variants on human obesity and obesity-related metabolism remains uncertain.
  • Variant 2:
    IRX3:c.*3961G>A
    Gene:
    IRX3
    Genomic location:
    chr16:54313637
    dbSNP ID:
    rs8053360
    Target disease:
    Obesity(DOID_9970)
    Effect type:
    Expressivity 
    Modifier effect:
    Risk factor 
    Evidence:
    P=0.146 
    Effect:
    The rs8053360 CC and rs1126960 GG genotypes were associated with increased birth weight and BMI, especially in females.
    Reference:
    PMID28316138
    Title:
    IRX3 is a genetic modifier for birth weight, adolescent obesity and transaminase metabolism.
    Species studied:
    Human
    Abstract:
    IRX3 expression has been functionally associated in obesity-associated long-distance susceptibility loci, but the effect of the IRX3 genetic variants on human obesity and obesity-related metabolism remains uncertain.