Disorder "Obesity"
Found 54 records
Disorder information
Disorder name:
Obesity 
Disoder ID:
OMIM entry:
Definition:
Accumulation of substantial excess body fat. 
Modifier statisitcs
Record:
54 
Gene:
25 
Variant:
38 
Reference:
Effect type:
Expressivity(54)  
Modifier effect:
HDL-C and Triglyceride SNP*Tx Interaction association(11) ,Risk factor(9) ,1-Year log(TRIG) Change(5) ,Altered life span(5) ,1-Year HDL Change(4) ,Altered waist circumference(4) ,Altered waist-to-height ratio(3) ,Altered waist-to-hip ratio(3) ,Altered LDL(2) ,Altered indices of obesity(2) ,Altered obesity(2) ,Altered cholesterol(1) ,Altered hepatic triglyceride content(1) ,Altered severity(1) ,Baseline HDL Change(1)  
Modifier gene Variant Effect type Modifier effect Evidence Effect PubMed ID
ZPR1 ZNF259:rs12286037 Expressivity  HDL-C and Triglyceride SNP*Tx Interaction association  P=0.0472  This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more more
UCP3 UCP3:rs15763 Expressivity  Altered waist circumference  P=0.018  Associated with abdominal obesity at the baselinemore more
UCP3:rs15763 Expressivity  Altered waist-to-height ratio  P=0.024  Associated with abdominal obesity at the baselinemore more
UCP3:rs1726745 Expressivity  Altered waist-to-height ratio  P=0.003  Associated with abdominal obesity at the baselinemore more
UCP3:rs1726745 Expressivity  Altered waist circumference  P=0.031  Associated with abdominal obesity at the baselinemore more
UCP3:rs653529 Expressivity  Altered waist circumference  P=0.009  Associated with abdominal obesity at the baselinemore more
UCP3:rs653529 Expressivity  Altered waist-to-hip ratio  P=0.011  Associated with abdominal obesity at the baselinemore more
UCP3:rs653529 Expressivity  Altered waist-to-height ratio  P=0.022  Associated with abdominal obesity at the baselinemore more
UCP3:rs659366 Expressivity  Altered waist-to-hip ratio  P=0.033  Associated with abdominal obesity at the baselinemore more
UCP3:rs659366 Expressivity  Altered waist circumference  P=0.048  Associated with abdominal obesity at the baselinemore more
Total 54,Each Page
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