Disorder "Obesity"
Found 54 records
Disorder information
Disorder name:
Obesity
Disoder ID:
OMIM entry:
Definition:
Accumulation of substantial excess body fat.
Modifier statisitcs
Record:
54
Gene:
25
Variant:
38
Reference:
9
Effect type:
Expressivity(54)
Modifier effect:
HDL-C and Triglyceride SNP*Tx Interaction association(11)
,Risk factor(9)
,1-Year log(TRIG) Change(5)
,Altered life span(5)
,1-Year HDL Change(4)
,Altered waist circumference(4)
,Altered waist-to-height ratio(3)
,Altered waist-to-hip ratio(3)
,Altered LDL(2)
,Altered indices of obesity(2)
,Altered obesity(2)
,Altered cholesterol(1)
,Altered hepatic triglyceride content(1)
,Altered severity(1)
,Baseline HDL Change(1)
Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
---|---|---|---|---|---|---|
ZPR1 | ZNF259:rs12286037 | Expressivity | HDL-C and Triglyceride SNP*Tx Interaction association | P=0.0472 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more |
UCP3 | UCP3:rs15763 | Expressivity | Altered waist circumference | P=0.018 | Associated with abdominal obesity at the baselinemore | more |
UCP3:rs15763 | Expressivity | Altered waist-to-height ratio | P=0.024 | Associated with abdominal obesity at the baselinemore | more | |
UCP3:rs1726745 | Expressivity | Altered waist-to-height ratio | P=0.003 | Associated with abdominal obesity at the baselinemore | more | |
UCP3:rs1726745 | Expressivity | Altered waist circumference | P=0.031 | Associated with abdominal obesity at the baselinemore | more | |
UCP3:rs653529 | Expressivity | Altered waist circumference | P=0.009 | Associated with abdominal obesity at the baselinemore | more | |
UCP3:rs653529 | Expressivity | Altered waist-to-hip ratio | P=0.011 | Associated with abdominal obesity at the baselinemore | more | |
UCP3:rs653529 | Expressivity | Altered waist-to-height ratio | P=0.022 | Associated with abdominal obesity at the baselinemore | more | |
UCP3:rs659366 | Expressivity | Altered waist-to-hip ratio | P=0.033 | Associated with abdominal obesity at the baselinemore | more | |
UCP3:rs659366 | Expressivity | Altered waist circumference | P=0.048 | Associated with abdominal obesity at the baselinemore | more |