Gene "XRCC2"
Found 1 record
Gene information
Gene symbol:
XRCC2
See related:
Ensembl: ENSG00000196584, Gene ID: 7516
Additive variants :
Undetected
Genetic interaction partners
No data
Modifier statisitcs
Record:
1 
Disorder:
1 
Vriant:
1 
Reference:
1 
Effect type:
Expressivity(1)  
Modifier effect:
Risk factor(1)  
Detail：
  • Variant 1:
    XRCC2:c.563G>A(p.Arg188His)
    Gene:
    XRCC2
    Genomic location:
    chr7:152346007
    dbSNP ID:
    rs3218536
    Target disease:
    Pancreatic Cancer(DOID_1793)
    Effect type:
    Expressivity 
    Modifier effect:
    Risk factor 
    Evidence:
    OR=2.32, 95% CI: (1.25-4.31) 
    Effect:
    XRCC2 Arg188His polymorphism may be one of the genetic modifiers for smoking-related pancreatic cancer
    Reference:
    PMID17986315
    Title:
    XRCC2 and XRCC3 gene polymorphism and risk of pancreatic cancer.
    Species studied:
    Human
    Abstract:
    XRCC2 and XRCC3 are key components of the homologous recombination (HR) machinery that repairs DNA double-strand breaks. We hypothesized that the altered HR repair capacity conferred by single nucleotide polymorphisms (SNPs) would modify individual susceptibility to sporadic pancreatic cancer.