Variant "UCP3:rs3781907"
Search result: 1 record
Variant information
Gene:
UCP3 
Variant:
UCP3:rs3781907 
Genomic location:
chr11:73716469(hg19) 
HGVS:
SO Term RefSeq
protein_coding NM_003356.3:c.541+306T>C
protein_coding NM_022803.2:c.541+306T>C
dbSNP ID:
rs3781907  
GWAS trait:
no data 
Modifier statisitcs
Record:
1 
Disorder:
1 
Reference:
1 
Effect type:
Expressivity(1)  
Modifier effect:
Risk factor(1)  
Detail：
  • Target disease:
    Type 2 Diabetes Mellitus (DOID_9352)
    Effect type:
    Expressivity 
    Modifier effect:
    Risk factor 
    Evidence:
    HR=1.48, 95% CI: 1.09-2.00 
    Effect:
    The subjects with the rs3781907-G allele were at a higher risk for T2DM when compared with subjects with AA genotype, with hazard ratio (HR) of 1.48 (95%CI 1.09-2.00), p/q 0.011/0.100.
    Reference:
    PMID19769793
    Title:
    Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study.
    Species studied:
    Human
    Abstract:
    We explored the associations of three variants in the uncoupling protein 2 (UCP2) gene, one variant in the UCP2-UCP3 intergenic region and five variants in the uncoupling protein 3 (UCP3) gene with obesity and diabetes related traits in subjects with impaired glucose tolerance participating in Finnish Diabetes Prevention Study. Altogether 507 overweight individuals (body mass index: 31.2 +/- 4.5 kg/m2, age: 55 +/- 7 years) for whom DNA was available were randomized to either an intensified diet and physical activity group or to a conventional care control group.