Disorder "Type 2 Diabetes Mellitus"
Found 50 records
Disorder information
Disorder name:
Type 2 Diabetes Mellitus
Disoder ID:
OMIM entry:
Synonyms:
non-insulin-dependent diabetes mellitus, type II diabetes mellitus, NIDDM
Definition:
A type of diabetes mellitus initially characterized by insulin resistance and hyperinsulinemia and subsequently by glucose interolerance and hyperglycemia.
Modifier statisitcs
Record:
50
Gene:
18
Variant:
36
Reference:
14
Effect type:
Expressivity(39)
,Penetrance(11)
Modifier effect:
Altered incidence(11)
,HDL-C and Triglyceride SNP*Tx Interaction association(11)
,Risk factor(9)
,Altered level of glycaemia(6)
,1-Year log(TRIG) Change(5)
,1-Year HDL Change(4)
,Altered susceptibility(3)
,Baseline HDL Change(1)
Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
---|---|---|---|---|---|---|
ZPR1 | ZNF259:rs12286037 | Expressivity | HDL-C and Triglyceride SNP*Tx Interaction association | P=0.0472 | This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more | more |
UCP3 | UCP3:rs3781907 | Expressivity | Risk factor | HR=1.48, 95% CI: 1.09-2.00 | The subjects with the rs3781907-G allele were at a higher risk for T2DM when compared with subjects with AA genotype, with hazard ratio (HR) of 1.48 (95%CI 1.09-2.00), p/q 0.011/0.100.more | more |
UCP2 | UCP2:c.-866G/A | Expressivity | Risk factor | OR=0.51; 95% CI: 0.3-0.8; P=0.003 | The -866G/A SNP is associated with T2D.more | more |
UCP2:c.InsIns | Expressivity | Risk factor | HR=2.53, 95% CI: 1.11-5.73,p/q0.027/0.243. | Subjects in the intervention group carrying the UCP2 InsIns genotype were at a higher risk compared with subjects with Del allele, with HR 2.53 (95%CI 1.11-5.73), p/q 0.027/0.243.more | more | |
TCF7L2 | TCF7L2:c.876-1026C>T | Expressivity | Altered susceptibility | OR=1.184, 95% CI: 1.008-1.391 | rs290487T was found to be significantly associated with disease susceptibility (p=0.039)more | more |
SUMO4 | SUMO4:c.163G>A(p.Val55Met) | Expressivity | Altered susceptibility | P=0.018, OR=1.72, 95% CI: 1.1-2.7 | SUMO4 c.163 G>A polymorphism is associated with the susceptibility to diabetic nephropathy in north Indian subjects with type 2 diabetes.more | more |
SUMO4:c.163G>A(p.Val55Met) | Expressivity | Risk factor | OR=1.46; 95% CI: 1.08-1.93; P=0.01, chi(2) test | These data suggest the contribution of the SUMO4 Met55Val polymorphism to both type 1 and type 2 diabetes susceptibility in the Japanese population.more | more | |
SUMO4:c.163G>A(p.Val55Met) | Expressivity | Risk factor | OR=1.18, 95% CI: 1.10-1.28, P=1.63×10(-5) | The SUMO4 M55V gene polymorphism (rs237025) may be associated with an increased risk of type 2 diabetes mellitus (T2DM).more | more | |
SUMO4:c.163G>A(p.Val55Met) | Expressivity | Risk factor | P=0,000, χ2=24,47, OR=0.23, %95 CI: 0,12-0,42 | The number of SUMO4 M55V MM genotype and M allele carriers was significantly higher in patients compared to the control groupmore | more | |
SUMO4:c.163G>A(p.Val55Met) | Expressivity | Altered susceptibility | Assessment of genotype–phenotype associations | In Taiwan the SUMO4 Met 55Val polymorphism is associated with susceptibility to T2DM and Type 2 diabetic patients with GG genotype have worse glycemic control.more | more |