Disorder "Type 2 Diabetes Mellitus"
Found 50 records
Disorder information
Disorder name:
Type 2 Diabetes Mellitus 
Disoder ID:
OMIM entry:
Synonyms:
non-insulin-dependent diabetes mellitus, type II diabetes mellitus, NIDDM 
Definition:
A type of diabetes mellitus initially characterized by insulin resistance and hyperinsulinemia and subsequently by glucose interolerance and hyperglycemia. 
Modifier statisitcs
Record:
50 
Gene:
18 
Variant:
36 
Reference:
14 
Effect type:
Expressivity(39) ,Penetrance(11)  
Modifier effect:
Altered incidence(11) ,HDL-C and Triglyceride SNP*Tx Interaction association(11) ,Risk factor(9) ,Altered level of glycaemia(6) ,1-Year log(TRIG) Change(5) ,1-Year HDL Change(4) ,Altered susceptibility(3) ,Baseline HDL Change(1)  
Modifier gene Variant Effect type Modifier effect Evidence Effect PubMed ID
ZPR1 ZNF259:rs12286037 Expressivity  HDL-C and Triglyceride SNP*Tx Interaction association  P=0.0472  This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.more more
UCP3 UCP3:rs3781907 Expressivity  Risk factor  HR=1.48, 95% CI: 1.09-2.00  The subjects with the rs3781907-G allele were at a higher risk for T2DM when compared with subjects with AA genotype, with hazard ratio (HR) of 1.48 (95%CI 1.09-2.00), p/q 0.011/0.100.more more
UCP2 UCP2:c.-866G/A Expressivity  Risk factor  OR=0.51; 95% CI: 0.3-0.8; P=0.003  The -866G/A SNP is associated with T2D.more more
UCP2:c.InsIns Expressivity  Risk factor  HR=2.53, 95% CI: 1.11-5.73,p/q0.027/0.243.  Subjects in the intervention group carrying the UCP2 InsIns genotype were at a higher risk compared with subjects with Del allele, with HR 2.53 (95%CI 1.11-5.73), p/q 0.027/0.243.more more
TCF7L2 TCF7L2:c.876-1026C>T Expressivity  Altered susceptibility  OR=1.184, 95% CI: 1.008-1.391  rs290487T was found to be significantly associated with disease susceptibility (p=0.039)more more
SUMO4 SUMO4:c.163G>A(p.Val55Met) Expressivity  Altered susceptibility  P=0.018, OR=1.72, 95% CI: 1.1-2.7  SUMO4 c.163 G>A polymorphism is associated with the susceptibility to diabetic nephropathy in north Indian subjects with type 2 diabetes.more more
SUMO4:c.163G>A(p.Val55Met) Expressivity  Risk factor  OR=1.46; 95% CI: 1.08-1.93; P=0.01, chi(2) test  These data suggest the contribution of the SUMO4 Met55Val polymorphism to both type 1 and type 2 diabetes susceptibility in the Japanese population.more more
SUMO4:c.163G>A(p.Val55Met) Expressivity  Risk factor  OR=1.18, 95% CI: 1.10-1.28, P=1.63×10(-5)  The SUMO4 M55V gene polymorphism (rs237025) may be associated with an increased risk of type 2 diabetes mellitus (T2DM).more more
SUMO4:c.163G>A(p.Val55Met) Expressivity  Risk factor  P=0,000, χ2=24,47, OR=0.23, %95 CI: 0,12-0,42  The number of SUMO4 M55V MM genotype and M allele carriers was significantly higher in patients compared to the control groupmore more
SUMO4:c.163G>A(p.Val55Met) Expressivity  Altered susceptibility  Assessment of genotype–phenotype associations  In Taiwan the SUMO4 Met 55Val polymorphism is associated with susceptibility to T2DM and Type 2 diabetic patients with GG genotype have worse glycemic control.more more
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