Variant "UCP3:rs659366"
Search results: 2 records
Variant information
Gene:
UCP3 
Variant:
UCP3:rs659366 
Genomic location:
chr11:73694754(hg19) 
HGVS:
SO Term RefSeq
protein_coding NM_003355.2:c.-5331G>A
UCP2-UCP3:n.73694754C>T
dbSNP ID:
rs659366  
GWAS trait:
no data 
Modifier statisitcs
Record:
2 
Disorder:
1 
Reference:
1 
Effect type:
Expressivity(2)  
Modifier effect:
Altered waist circumference(1) ,Altered waist-to-hip ratio(1)  
Details：
  • Target disease:
    Obesity (DOID_9970)
    Effect type:
    Expressivity 
    Modifier effect:
    Altered waist-to-hip ratio 
    Evidence:
    P=0.033 
    Effect:
    Associated with abdominal obesity at the baseline
    Reference:
    PMID19769793
    Title:
    Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study.
    Species studied:
    Human
    Abstract:
    We explored the associations of three variants in the uncoupling protein 2 (UCP2) gene, one variant in the UCP2-UCP3 intergenic region and five variants in the uncoupling protein 3 (UCP3) gene with obesity and diabetes related traits in subjects with impaired glucose tolerance participating in Finnish Diabetes Prevention Study. Altogether 507 overweight individuals (body mass index: 31.2 +/- 4.5 kg/m2, age: 55 +/- 7 years) for whom DNA was available were randomized to either an intensified diet and physical activity group or to a conventional care control group.
  • Target disease:
    Obesity (DOID_9970)
    Effect type:
    Expressivity 
    Modifier effect:
    Altered waist circumference 
    Evidence:
    P=0.048 
    Effect:
    Associated with abdominal obesity at the baseline
    Reference:
    PMID19769793
    Title:
    Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study.
    Species studied:
    Human
    Abstract:
    We explored the associations of three variants in the uncoupling protein 2 (UCP2) gene, one variant in the UCP2-UCP3 intergenic region and five variants in the uncoupling protein 3 (UCP3) gene with obesity and diabetes related traits in subjects with impaired glucose tolerance participating in Finnish Diabetes Prevention Study. Altogether 507 overweight individuals (body mass index: 31.2 +/- 4.5 kg/m2, age: 55 +/- 7 years) for whom DNA was available were randomized to either an intensified diet and physical activity group or to a conventional care control group.