Variant "ZNF259:rs12286037"
Search results: 2 records
Variant information
Gene:
ZPR1 
Variant:
ZNF259:rs12286037 
dbSNP ID:
rs12286037  
GWAS trait:
lipoprotein-associated phospholipase A(2) measurement,triglyceride measurement,metabolic syndrome 
Modifier statisitcs
Record:
2 
Disorder:
2 
Reference:
1 
Effect type:
Expressivity(2)  
Modifier effect:
HDL-C and Triglyceride SNP*Tx Interaction association(2)  
Details：
  • Target disease:
    Obesity (DOID_9970)
    Effect type:
    Expressivity 
    Modifier effect:
    HDL-C and Triglyceride SNP*Tx Interaction association 
    Evidence:
    P=0.0472 
    Effect:
    This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.
    Reference:
    PMID23861364
    Title:
    Do genetic modifiers of high-density lipoprotein cholesterol and triglyceride levels also modify their response to a lifestyle intervention in the setting of obesity and type-2 diabetes mellitus: The Action for Health in Diabetes (Look AHEAD) study.
    Species studied:
    Human
    Abstract:
    High-density lipoprotein cholesterol (HDL-C) and triglycerides are cardiovascular risk factors susceptible to lifestyle behavior modification and genetics. We hypothesized that genetic variants identified by genome-wide association studies as associated with HDL-C or triglyceride levels modify 1-year treatment response to an intensive lifestyle intervention, relative to a usual care of diabetes mellitus support and education.
  • Target disease:
    Type 2 Diabetes Mellitus (DOID_9352)
    Effect type:
    Expressivity 
    Modifier effect:
    HDL-C and Triglyceride SNP*Tx Interaction association 
    Evidence:
    P=0.0472 
    Effect:
    This is the first study to identify genetic variants modifying lipid responses to a randomized lifestyle behavior intervention in overweight or obese individuals with diabetes mellitus. The effects of genetic factors on lipid changes may differ from the effects on baseline lipids and are modifiable by behavioral intervention.
    Reference:
    PMID23861364
    Title:
    Do genetic modifiers of high-density lipoprotein cholesterol and triglyceride levels also modify their response to a lifestyle intervention in the setting of obesity and type-2 diabetes mellitus: The Action for Health in Diabetes (Look AHEAD) study.
    Species studied:
    Human
    Abstract:
    High-density lipoprotein cholesterol (HDL-C) and triglycerides are cardiovascular risk factors susceptible to lifestyle behavior modification and genetics. We hypothesized that genetic variants identified by genome-wide association studies as associated with HDL-C or triglyceride levels modify 1-year treatment response to an intensive lifestyle intervention, relative to a usual care of diabetes mellitus support and education.