Detail
Experiment ID:
EXP00003
Reference:
- Title: A microRNA polycistron as a potential human oncogene.
- Author: He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ, Hammond SM
- Journal: Nature.2005 Jun 09;435(7043):828-33.doi:10.1038/nature03552.
- Abstract: To date, more than 200 microRNAs have been described in humans; however, the precise functions of these regulatory, non-coding RNAs remains largely obscure. One cluster of microRNAs, the mir-17-92 polycistron, is located in a region of DNA that is amplified in human B-cell lymphomas. Here we compared B-cell lymphoma samples and cell lines to normal tissues, and found that the levels of the primary or mature microRNAs derived from the mir-17-92 locus are often substantially increased in these cancers. Enforced expression of the mir-17-92 cluster acted with c-myc expression to accelerate tumour development in a mouse B-cell lymphoma model. Tumours derived from haematopoietic stem cells expressing a subset of the mir-17-92 cluster and c-myc could be distinguished by an absence of apoptosis that was otherwise prevalent in c-myc-induced lymphomas. Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir-17-92 cluster as a potential human oncogene.
- PMID: 15944707
Expression Profile:
Design and Sample:
- Cancer Type:lymphoma
- Cancer SubType:B cell lymphoma
- Cell Line:OCI-Ly8
- Experimental Design:cancer vs normal
- Case Sample:OCI-Ly8
- Control Sample:Normal B cell
- Num of Case:4
- Num of Control:4
- Quantification Software:Limma
- Num of miRNAs:190
Identification:
- Num of Up:38
- Num of Down:36
Time Info:
- Create Time2016-03-14
- Update Time:2021-05-27
Status:
miRNA ID | Cancer Type | Design | logFC | AveExpr | T value | P value | adj Pvalue | Status | Plot |
---|