2587
microRNAs
36
Cancer Types
99
Cancer Subtypes
209
Expression datasets
436
Experiments
22687
Sample Size
Welcome to dbDEMC
dbDEMC (database of Differentially Expressed MiRNAs in human Cancers) is an integrated database that
designed to store and display differentially expressed microRNAs (miRNAs) in human cancers detected by
high-throughput methods. In this updated version of dbDEMC, a total of 209 newly published data sets were
collected from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA). The limma package embedded
in R (http://www.r-project.org/) was used to screen the differentially expressed miRNAs from different types
of experiments, which include the cancer versus normal comparison, cancer subtypes comparison, cancer grade
comparision, cancer outcome comparision, blood sample comparision, respectively. The current version
contains 2587 differentially expressed miRNAs in 36 cancer types, curated from 436 experiments. An
easy-to-use interface was constructed to facilitate the query and browse the results in the database. In
addition, an enhanced miRNA page is provide to demonstrate the basic miRNA description, expression profiles
across multiple caners in each analysis type, related analysis experiments and results from low throughput
validation assays. For a set of miRNAs and multiple cancer types, differential expression profile can be
visualized in a heatmap to explore the difference and similarity between cancers. We try to make dbDEMC a
valuable resource to facilitate cancer research and contribute to miRNA related biomarker discovery for
cancer.
News
- The first version of dbDEMC is released April 1st, 2010
- Newly published miRNA expression data set were collected Dec 1st, 2015
- Publication resurces was collected Dec 25th, 2015
- Differentially expressed miRNA analysis piplie was constructed Jan 20th, 2016
- Identification for the DEMs was finished May 1st, 2016
- The updateded version of dbDEMC was reconstructed and modified. May 18th, 2016
- Advanced function was integrated to faciliate data management May 25th, 2016
- The second version of dbDEMC was released Jun 15th, 2016