Detail
Experiment ID:
EXP00102
Reference:
- Title: Integrative genomic profiling of human prostate cancer.
- Author: Taylor BS, Schultz N, Hieronymus H, Gopalan A, Xiao Y, Carver BS, Arora VK, Kaushik P, Cerami E, Reva B, Antipin Y, Mitsiades N, Landers T, Dolgalev I, Major JE, Wilson M, Socci ND, Lash AE, Heguy A, Eastham JA, Scher HI, Reuter VE, Scardino PT, Sander C, Sawyers CL, Gerald WL
- Journal: Cancer cell.2010 Jul 13;18(1):11-22.doi:10.1016/j.ccr.2010.05.026.
- Abstract: Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Concordant assessment of DNA copy number, mRNA expression, and focused exon resequencing in 218 prostate cancer tumors identified the nuclear receptor coactivator NCOA2 as an oncogene in approximately 11% of tumors. Additionally, the androgen-driven TMPRSS2-ERG fusion was associated with a previously unrecognized, prostate-specific deletion at chromosome 3p14 that implicates FOXP1, RYBP, and SHQ1 as potential cooperative tumor suppressors. DNA copy-number data from primary tumors revealed that copy-number alterations robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score. The genomic and clinical outcome data from these patients are now made available as a public resource.
- PMID: 20579941
Expression Profile:
- Description:MicroRNA expression data for human primary and metastatic prostate cancer samples and control normal adjacent benign prostate
- Organism:Homo sapiens
- Source:GEO
- Source ID:GSE21036
- Platform: GPL8227
- Number of samples:142
- Overall design:Human prostate samples were profiled on Agilent microRNA V2 arrays per manufacturer's instructions.
- Instrument:Agilent-019118 Human miRNA Microarray 2.0 G4470B (miRNA ID version)
Design and Sample:
- Cancer Type:prostate cancer
- Cancer SubType:N/A
- Cell Line:N/A
- Experimental Design:metastasis
- Case Sample:metastatic prostate cancer
- Control Sample:prostate cancer
- Num of Case:14
- Num of Control:99
- Quantification Software:Limma
- Num of miRNAs:373
Identification:
- Num of Up:129
- Num of Down:97
Time Info:
- Create Time2016-03-14
- Update Time:2021-05-27
Status:
| miRNA ID | Cancer Type | Design | logFC | AveExpr | T value | P value | adj Pvalue | Status | Plot |
|---|