Detail
Experiment ID:
EXP00328
Reference:
- Title: Treatment-independent miRNA signature in blood of Wilms tumor patients.
- Author: Schmitt J, Backes C, Nourkami-Tutdibi N, Leidinger P, Deutscher S, Beier M, Gessler M, Graf N, Lenhof HP, Keller A, Meese E
- Journal: BMC genomics.2012 Aug 07;13:379.doi:10.1186/1471-2164-13-379.
- Abstract: Blood-born miRNA signatures have recently been reported for various tumor diseases. Here, we compared the miRNA signature in Wilms tumor patients prior and after preoperative chemotherapy according to SIOP protocol 2001., We did not find a significant difference between miRNA signature of both groups. However both, Wilms tumor patients prior and after chemotherapy showed a miRNA signature different from healthy controls. The signature of Wilms tumor patients prior to chemotherapy showed an accuracy of 97.5% and of patients after chemotherapy an accuracy of 97.0%, each as compared to healthy controls., Our results provide evidence for a blood-born Wilms tumor miRNA signature largely independent of four weeks preoperative chemotherapy treatment.
- PMID: 22871070
Expression Profile:
- Description:miRNA profiles of Wilms tumor patients and controls
- Organism:Homo sapiens
- Source:GEO
- Source ID:GSE38419
- Platform: GPL9040
- Number of samples:42
- Overall design:This project analyzes peripheral blood profiles of Wilms tumor patients and controls in order to detect specific profiles. n=19 normal controls and n=23 Wilms tumor patients were screened for the complete miRNA repertoire. Please note that each miRNA has been measured in seven replicates and the median of the replica has been computed.
- Instrument:febit Homo Sapiens miRBase 13.0
Design and Sample:
- Cancer Type:kidney cancer
- Cancer SubType:wilms tumor
- Cell Line:N/A
- Experimental Design:blood
- Case Sample:blood from kidney cancer
- Control Sample:normal blood
- Num of Case:23
- Num of Control:19
- Quantification Software:limma
- Num of miRNAs:848
Identification:
- Num of Up:153
- Num of Down:155
Time Info:
- Create Time2016-03-14
- Update Time:2021-05-27
Status:
| miRNA ID | Cancer Type | Design | logFC | AveExpr | T value | P value | adj Pvalue | Status | Plot |
|---|