Detail
Experiment ID:
EXP00437
Reference:
- Title: Molecular Features of Subtype-Specific Progression from Ductal Carcinoma In Situ to Invasive Breast Cancer.
- Author: Lesurf R, Aure MR, Mørk HH, Vitelli V,, Lundgren S, Børresen-Dale AL, Kristensen V, Wärnberg F, Hallett M, Sørlie T
- Journal: Cell reports.2016 07 26;16(4):1166-1179.doi:10.1016/j.celrep.2016.06.051.
- Abstract: Breast cancer consists of at least five main molecular "intrinsic" subtypes that are reflected in both pre-invasive and invasive disease. Although previous studies have suggested that many of the molecular features of invasive breast cancer are established early, it is unclear what mechanisms drive progression and whether the mechanisms of progression are dependent or independent of subtype. We have generated mRNA, miRNA, and DNA copy-number profiles from a total of 59 in situ lesions and 85 invasive tumors in order to comprehensively identify those genes, signaling pathways, processes, and cell types that are involved in breast cancer progression. Our work provides evidence that there are molecular features associated with disease progression that are unique to the intrinsic subtypes. We additionally establish subtype-specific signatures that are able to identify a small proportion of pre-invasive tumors with expression profiles that resemble invasive carcinoma, indicating a higher likelihood of future disease progression.
- PMID: 27396337
Expression Profile:
- Description:Molecular features of subtype-specific progression from ductal carcinoma in situ to invasive breast cancer
- Organism:Homo sapiens
- Source:GEO
- Source ID:GSE59247
- Platform: GPL15019
- Number of samples:48
- Overall design:One-color design, totaling 48 arrays and 41 unique tissues. Arrays consist of 4 normal controls (1 unique), 28 DCIS lesions (26 unique), and 16 small invasive breast cancers (14 unique).
- Instrument:Agilent-031181 Unrestricted_Human_miRNA_V16.0_Microarray 030840 (miRBase release 14.0 miRNA ID version)
Design and Sample:
- Cancer Type:breast cancer
- Cancer SubType:N/A
- Cell Line:N/A
- Experimental Design:cancer vs normal
- Case Sample:ductal carcinoma in situ (DCIS)
- Control Sample:normal breast tissue
- Num of Case:28
- Num of Control:4
- Quantification Software:Limma
- Num of miRNAs:1205
Identification:
- Num of Up:35
- Num of Down:65
Time Info:
- Create Time2021-06-04
- Update Time:2021-06-07
Status:
| miRNA ID | Cancer Type | Design | logFC | AveExpr | T value | P value | adj Pvalue | Status | Plot |
|---|