Dr AFC

Target ID	Name	Interaction
T0363	Serine/threonine-protein kinase mTOR	inhibitor
T1014	mTOR Complex 1	inhibitor
T1015	mTOR Complex 2	inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID	28751568	Target ID	T0363
Uniprot ID	Serine/threonine-protein kinase mTOR	Name	Serine/threonine-protein kinase mTOR
Model	mice	Fibrosis Disease	Aortic fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID	28408970	Target ID
Uniprot ID		Name
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID	28194671	Target ID	T0363
Uniprot ID	Serine/threonine-protein kinase mTOR	Name	Serine/threonine-protein kinase mTOR
Model	vitro,rat	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSC activation
Process III
Mechanism

Reference Record 4

PubMed ID	27798166	Target ID	T0363
Uniprot ID	Serine/threonine-protein kinase mTOR	Name	Serine/threonine-protein kinase mTOR
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting mTOR signaling

Reference Record 5

PubMed ID	27663762	Target ID	T0363
Uniprot ID	Serine/threonine-protein kinase mTOR	Name	Serine/threonine-protein kinase mTOR
Model	mice	Fibrosis Disease	Pulmonary fibrosis
Process I	regulate cytokines and growth factors
Process II	macrophage accumulation
Process III	prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID	27694325	Target ID	T0363
Uniprot ID	Serine/threonine-protein kinase mTOR	Name	Serine/threonine-protein kinase mTOR
Model	vitro,rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting mTOR pathway

Reference Record 7

PubMed ID	27257474	Target ID	T0363
Uniprot ID	Serine/threonine-protein kinase mTOR	Name	Serine/threonine-protein kinase mTOR
Model	mice	Fibrosis Disease	Muscle fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting mTOR signaling

Reference Record 8

PubMed ID	26980426	Target ID
Uniprot ID		Name
Model	vitro	Fibrosis Disease	Abdominal fibrosis
Process I
Process II	fibroblasts proliferation
Process III
Mechanism

Reference Record 9

PubMed ID	26755732	Target ID	T0363
Uniprot ID	Serine/threonine-protein kinase mTOR	Name	Serine/threonine-protein kinase mTOR
Model	vitro	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID	26538632	Target ID
Uniprot ID		Name
Model	zebrafish	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID	26382847	Target ID
Uniprot ID		Name
Model	vitro,human,mice	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 12

PubMed ID	25547416	Target ID
Uniprot ID		Name
Model	vitro,rat	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II	EMT
Process III	prevenet collagen deposition
Mechanism	Targeting mTOR signaling

Reference Record 13

PubMed ID	25542803	Target ID
Uniprot ID		Name
Model	vitro,rat	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 14

PubMed ID	24983318	Target ID	T0363
Uniprot ID	Serine/threonine-protein kinase mTOR	Name	Serine/threonine-protein kinase mTOR
Model	mice	Fibrosis Disease	Liver fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting AMPK/mTORC1 axis

Reference Record 15

PubMed ID	24835866	Target ID	T0363
Uniprot ID	Serine/threonine-protein kinase mTOR	Name	Serine/threonine-protein kinase mTOR
Model	vitro	Fibrosis Disease	Keloid
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting mTOR pathways

Reference Record 16

PubMed ID	24404143	Target ID
Uniprot ID		Name
Model	rat	Fibrosis Disease	Liver fibrosis
Process I	attenue inflammation
Process II	cells proliferation
Process III	prevenet collagen deposition
Mechanism	Targeting AKT/mTOR signaling pathway

Reference Record 17

PubMed ID	24106124	Target ID
Uniprot ID		Name
Model	vitro,rabbit	Fibrosis Disease	Scar
Process I
Process II	fibroblasts proliferation,myofibroblasts differentiation
Process III	prevenet collagen deposition
Mechanism

Reference Record 18

PubMed ID	23907484	Target ID
Uniprot ID		Name
Model	vitro	Fibrosis Disease	Fibrosis
Process I
Process II	EMT
Process III
Mechanism

Reference Record 19

PubMed ID	23561805	Target ID
Uniprot ID		Name
Model	mice	Fibrosis Disease	Bronchiolitis fibrosis
Process I
Process II	fibroblasts migration
Process III
Mechanism

Reference Record 20

PubMed ID	23364979	Target ID
Uniprot ID		Name
Model	vitro	Fibrosis Disease	Idiopathic pulmonary fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting mTOR/p70S6K pathway

Reference Record 21

PubMed ID	22815997	Target ID
Uniprot ID		Name
Model	vitro,human,mice	Fibrosis Disease	Idiopathic pulmonary fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 22

PubMed ID	22470459	Target ID
Uniprot ID		Name
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II	myofibroblasts activation,cells differentiation,cells proliferation
Process III	prevenet collagen deposition
Mechanism	Targeting mTOR signaling

Reference Record 23

PubMed ID	22343118	Target ID	T1014
Uniprot ID	mTOR Complex 1	Name	mTOR Complex 1
Model	mice	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II	cells apoptosis
Process III	prevenet collagen deposition
Mechanism

Reference Record 24

PubMed ID	22343118	Target ID	T1015
Uniprot ID	mTOR Complex 2	Name	mTOR Complex 2
Model	mice	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II	cells apoptosis
Process III	prevenet collagen deposition
Mechanism

Reference Record 25

PubMed ID	21997369	Target ID
Uniprot ID		Name
Model	vitro,mice	Fibrosis Disease	Cystic fibrosis
Process I	attenue inflammation
Process II
Process III
Mechanism

Reference Record 26

PubMed ID	20506342	Target ID
Uniprot ID		Name
Model	mice	Fibrosis Disease	Systemic sclerosis
Process I	attenue inflammation
Process II	fibroblasts proliferation
Process III	prevenet collagen deposition
Mechanism

Reference Record 27

PubMed ID	20075061	Target ID
Uniprot ID		Name
Model	mice	Fibrosis Disease	Renal fibrosis
Process I
Process II	cells proliferation,cells apoptosis
Process III
Mechanism	Targeting Pkd1

Reference Record 28

PubMed ID	19956083	Target ID
Uniprot ID		Name
Model	mice	Fibrosis Disease	Peritoneal fibrosis
Process I
Process II	EMT
Process III	prevenet collagen deposition
Mechanism

Reference Record 29

PubMed ID	19846571	Target ID
Uniprot ID		Name
Model	rat	Fibrosis Disease	Renal fibrosis
Process I
Process II	fibroblasts proliferation,myofibroblasts acccumulation
Process III	prevenet collagen deposition
Mechanism	Targeting Abl mTORC1

Reference Record 30

PubMed ID	19790156	Target ID	T0363
Uniprot ID	Serine/threonine-protein kinase mTOR	Name	Serine/threonine-protein kinase mTOR
Model	vitro,rat	Fibrosis Disease	Liver fibrosis
Process I
Process II	EMT,HSCs proliferation
Process III	prevenet collagen deposition
Mechanism

Reference Record 31

PubMed ID	19433312	Target ID
Uniprot ID		Name
Model	vitro,human,mice	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 32

PubMed ID	19244201	Target ID	T0363
Uniprot ID	Serine/threonine-protein kinase mTOR	Name	Serine/threonine-protein kinase mTOR
Model	mice	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 33

PubMed ID	17804674	Target ID	T1014
Uniprot ID	mTOR Complex 1	Name	mTOR Complex 1
Model	rat	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 34

PubMed ID	17804674	Target ID	T1015
Uniprot ID	mTOR Complex 2	Name	mTOR Complex 2
Model	rat	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 35

PubMed ID	17550925	Target ID
Uniprot ID		Name
Model	rat	Fibrosis Disease	Renal fibrosis
Process I
Process II	cells proliferation,myofibroblasts accumulation
Process III	prevenet collagen deposition
Mechanism

Reference Record 36

PubMed ID	17437482	Target ID	T0363
Uniprot ID	Serine/threonine-protein kinase mTOR	Name	Serine/threonine-protein kinase mTOR
Model	vitro	Fibrosis Disease	Keloid
Process I
Process II	fibroblasts proliferation
Process III	prevenet collagen deposition
Mechanism

Reference Record 37

PubMed ID	17200203	Target ID	T0363
Uniprot ID	Serine/threonine-protein kinase mTOR	Name	Serine/threonine-protein kinase mTOR
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I
Process II	cells proliferation,cells accumulation
Process III	prevenet collagen deposition
Mechanism	Targeting IGF-I receptor/mTOR/p70 S6 kinase signaling

Reference Record 38

PubMed ID	17050028	Target ID	T0363
Uniprot ID	Serine/threonine-protein kinase mTOR	Name	Serine/threonine-protein kinase mTOR
Model	rat	Fibrosis Disease	Liver fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 39

PubMed ID	16877971	Target ID	T0363
Uniprot ID	Serine/threonine-protein kinase mTOR	Name	Serine/threonine-protein kinase mTOR
Model	mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 40

PubMed ID	16841034	Target ID	T0363
Uniprot ID	Serine/threonine-protein kinase mTOR	Name	Serine/threonine-protein kinase mTOR
Model	vitro	Fibrosis Disease	Keloid
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 41

PubMed ID	16043946	Target ID	T0363
Uniprot ID	Serine/threonine-protein kinase mTOR	Name	Serine/threonine-protein kinase mTOR
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 42

PubMed ID	15808577	Target ID
Uniprot ID		Name
Model	rat	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 43

PubMed ID	28112218	Target ID	T1014
Uniprot ID	mTOR Complex 1	Name	mTOR Complex 1
Model	vitro	Fibrosis Disease	Fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Trial Record 1

ClinicalTrial ID	NCT00493194	Disease	Renal fibrosis
Phase	Phase 4	Status	Unknown
First Received	June 28, 2007	Last Verified	November 26, 2008
Sponsor	University Hospital, Antwerp

Trial Record 2

ClinicalTrial ID	NCT01462006	Disease	Idiopathic pulmonary fibrosis
Phase	Not Applicable	Status	Active, not recruiting
First Received	October 28, 2011	Last Verified	November 22, 2018
Sponsor	University of Virginia

Trial Record 3

ClinicalTrial ID	NCT00896012	Disease	Renal fibrosis
Phase	Phase 4	Status	Unknown
First Received	May 11, 2009	Last Verified	May 11, 2009
Sponsor	University at Buffalo

Trial Record 4

ClinicalTrial ID	NCT00188955	Disease	Renal fibrosis
Phase	Phase 4	Status	Completed
First Received	September 16, 2005	Last Verified	February 22, 2010
Sponsor	University of Manitoba

Trial Record 5

ClinicalTrial ID	NCT00040508	Disease	Renal fibrosis
Phase	Phase 2	Status	Completed
First Received	June 27, 2002	Last Verified	March 4, 2008
Sponsor	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

CAS ID:	53123-88-9
Molecular Formula:	C51H79NO13
Molecular Weight:	914.2 g/mol
Monoisotopic Mass:	913.5551 g/mol
Class:	Small Molecule
Natural Product:	No
Other Names:	WY-090217 \| RAPAMUNE \| SIROLIMUS \| RAPAMYCIN \| AY-22989
Analysis:	Drug repositioning mechanism analysis

InChI:	InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1	See All
InChI Key:	QFJCIRLUMZQUOT-HPLJOQBZSA-N
Smiles:	CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(/C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(/C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC)CC[C@H]1O	See All
Molfile:	Download

Rapamycin

Basic Information

Compound Structure and Identifier

Related Target

Related Fibrosis Property

Related Link