Serine/threonine-protein kinase mTOR

Basic Information

Uniprot ID: P42345
Secondary ID: Q4LE76
Symbol: MTOR
Other Name: FRAP,FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Kinase,Serine/threonine-protein kinase,Transferase

Target Classification

Category I Category II Category III
Intracellular Enzyme Kinase

Related Compound

Target ID Name Interaction
D0018 Rapamycin inhibitor
D0019 Everolimus inhibitor
D0025 Torkinib inhibitor
D0151 Omipalisib inhibitor
D0170 Dactolisib inhibitor
D0252 Sapanisertib inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 28751568 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model mice Fibrosis Disease Aortic fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 28751568 Compound ID D0019
CAS 159351-69-6 Name Everolimus
Model mice Fibrosis Disease Aortic fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 28679058 Compound ID D0025
CAS 1092351-67-1 Name Torkinib
Model vitro,rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 28194671 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II HSC activation
Process III
Mechanism

Reference Record 5

PubMed ID 27798166 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting mTOR signaling

Reference Record 6

PubMed ID 27663762 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model mice Fibrosis Disease Pulmonary fibrosis
Process I regulate cytokines and growth factors
Process II macrophage accumulation
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 27694325 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model vitro,rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting mTOR pathway

Reference Record 8

PubMed ID 27257474 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model mice Fibrosis Disease Muscle fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting mTOR signaling

Reference Record 9

PubMed ID 27103349 Compound ID D0151
CAS 1086062-66-9 Name Omipalisib
Model vitro,human Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II fibroblasts proliferation
Process III
Mechanism

Reference Record 10

PubMed ID 26755732 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID 25491391 Compound ID D0019
CAS 159351-69-6 Name Everolimus
Model human Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 12

PubMed ID 25258031 Compound ID D0170
CAS 915019-65-7 Name Dactolisib
Model vitro,mice Fibrosis Disease Systemic sclerosis
Process I
Process II fibroblasts activation
Process III prevenet collagen deposition
Mechanism Targeting PI3K/Akt/mTOR

Reference Record 13

PubMed ID 25162417 Compound ID D0252
CAS 1224844-38-5 Name Sapanisertib
Model vitro,mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 14

PubMed ID 24983318 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model mice Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting AMPK/mTORC1 axis

Reference Record 15

PubMed ID 24835866 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model vitro Fibrosis Disease Keloid
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting mTOR pathways

Reference Record 16

PubMed ID 24651621 Compound ID
CAS Name
Model vitro,human,mice,dog Fibrosis Disease Synovial fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 17

PubMed ID 23907484 Compound ID
CAS Name
Model vitro Fibrosis Disease Fibrosis
Process I
Process II EMT
Process III
Mechanism

Reference Record 18

PubMed ID 19790156 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II EMT,HSCs proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 19

PubMed ID 19244201 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 20

PubMed ID 18986012 Compound ID D0019
CAS 159351-69-6 Name Everolimus
Model rat Fibrosis Disease Peritoneal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 21

PubMed ID 17437482 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model vitro Fibrosis Disease Keloid
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 22

PubMed ID 17200203 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II cells proliferation,cells accumulation
Process III prevenet collagen deposition
Mechanism Targeting IGF-I receptor/mTOR/p70 S6 kinase signaling

Reference Record 23

PubMed ID 17050028 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 24

PubMed ID 16877971 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 25

PubMed ID 16841034 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model vitro Fibrosis Disease Keloid
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 26

PubMed ID 16043946 Compound ID D0018
CAS 53123-88-9 Name Rapamycin
Model rat Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism