Torkinib

Basic Information

CAS ID: 1092351-67-1
Molecular Formula: C16H16N6O
Molecular Weight: 308.4 g/mol
Monoisotopic Mass: 308.1386 g/mol
Class: Small Molecule
Natural Product: No
Other Names:
Analysis: Drug repositioning mechanism analysis

N NH HO N H2N N N

Compound Structure and Identifier

InChI: InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,21,23H,1-2H3,(H2,17,18,19)/b14-12+ See All
InChI Key: MTICIDWIKCANDD-WYMLVPIESA-N
Smiles: CC(C)N1N\C(=C\2/C=C3C=C(O)C=CC3=N2)\c4c(N)ncnc14 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0363 Serine/threonine-protein kinase mTOR inhibitor
T1014 mTOR Complex 1 inhibitor
T1015 mTOR Complex 2 inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 28679058 Target ID T0363
Uniprot ID Serine/threonine-protein kinase mTOR Name Serine/threonine-protein kinase mTOR
Model vitro,rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 22609986 Target ID T1014
Uniprot ID mTOR Complex 1 Name mTOR Complex 1
Model mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting ARAF

Reference Record 3

PubMed ID 22609986 Target ID T1015
Uniprot ID mTOR Complex 2 Name mTOR Complex 2
Model mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting ARAF

Related Link

PubChem: 25243800
ChEMBL: CHEMBL3988893