TGF-beta receptor type-1

Basic Information

Uniprot ID: P36897
Secondary ID: Q6IR47, Q706C0, Q706C1
Symbol: TGFBR1
Other Name: ALK5,TGFR-1,Activin A receptor type II-like protein kinase of 53kD,Activin receptor-like kinase 5,ALK-5,ALK5,Serinethreonine-protein kinase receptor R4,SKR4,TGF-beta type I receptor,Transforming growth factor-beta receptor type I,TGF-beta receptor type I,TbetaR-I
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Kinase,Receptor,Serine/threonine-protein kinase,Transferase

Target Classification

Category I Category II Category III
Extracellular Growth factor and receptor TGF-beta superfamily

Related Compound

Target ID Name Interaction
D0033 SB431542 inhibitor
D0435 A-77 inhibitor
D0443 SD-208 inhibitor
D0445 GW788388 inhibitor
D0496 LY364947 inhibitor
D0534 LY2109761 inhibitor
D1129 NP-40208 antagonist

Fibrosis Related Property

Reference Record 1

PubMed ID 28632033 Compound ID D0033
CAS 301836-41-9 Name SB431542
Model vitro Fibrosis Disease Subconjunctival fibrosis
Process I
Process II fibroblasts differentiation,HSCs migration
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 28553231 Compound ID D0033
CAS 301836-41-9 Name SB431542
Model vitro Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II fibroblasts proliferation, fibroblasts migration,fibroblasts-to-myofibroblasts
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 28181132 Compound ID D0033
CAS 301836-41-9 Name SB431542
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I
Process II cells migration,cells proliferation
Process III
Mechanism Targeting TGFβ-1/Smad signaling

Reference Record 4

PubMed ID 27186977 Compound ID D0033
CAS 301836-41-9 Name SB431542
Model mice Fibrosis Disease Muscle fibrosis
Process I
Process II myofibroblasts activation
Process III prevenet collagen deposition
Mechanism Targeting FAP

Reference Record 5

PubMed ID 26980767 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Pancreatic fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 26227022 Compound ID D0033
CAS 301836-41-9 Name SB431542
Model vitro,human Fibrosis Disease Systemic sclerosis
Process I
Process II
Process III
Mechanism Targeting IL-13

Reference Record 7

PubMed ID 24691207 Compound ID
CAS Name
Model vitro Fibrosis Disease Muscle fibrosis
Process I
Process II
Process III
Mechanism Targeting Myog

Reference Record 8

PubMed ID 24347485 Compound ID D0033
CAS 301836-41-9 Name SB431542
Model vitro,mice Fibrosis Disease Peritoneal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID 22328118 Compound ID D0033
CAS 301836-41-9 Name SB431542
Model vitro Fibrosis Disease Systemic sclerosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting Wnt/β-catenin pathway

Reference Record 10

PubMed ID 22245495 Compound ID D0033
CAS 301836-41-9 Name SB431542
Model vitro Fibrosis Disease Cardiac fibrosis
Process I
Process II EndMT,myofibroblasts differentiation
Process III
Mechanism

Reference Record 11

PubMed ID 19098325 Compound ID D0033
CAS 301836-41-9 Name SB431542
Model vitro,rabbit Fibrosis Disease Scar
Process I
Process II myofibroblasts differentiation,cells migration
Process III
Mechanism

Reference Record 12

PubMed ID 18451253 Compound ID D0435
CAS 607737-87-1 Name A-77
Model vitro,mice Fibrosis Disease Peribronchial fibrosis
Process I
Process II fibroblasts proliferation
Process III
Mechanism

Reference Record 13

PubMed ID 18229422 Compound ID D0443
CAS 627536-09-8 Name SD-208
Model mice Fibrosis Disease Fibrosis
Process I
Process II cells proliferation,cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 14

PubMed ID 18075500 Compound ID D0445
CAS 452342-67-5 Name GW788388
Model vitro Fibrosis Disease Renal fibrosis
Process I
Process II EMT,cells proliferation,cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 15

PubMed ID 28647476 Compound ID D0033
CAS 301836-41-9 Name SB431542
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation,HSCs proliferation
Process III
Mechanism

Reference Record 16

PubMed ID 22853924 Compound ID D0496
CAS 396129-53-6 Name LY364947
Model vitro,pig Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 17

PubMed ID 18034274 Compound ID D1129
CAS Name NP-40208
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 18

PubMed ID 28458155 Compound ID D0534
CAS 700874-71-1 Name LY2109761
Model vitro,human Fibrosis Disease Keloid
Process I
Process II fibroblasts proliferation,fibroblasts apoptosis
Process III prevenet collagen deposition
Mechanism Targeting TGF-β1/Smad signaling pathway