Palomid 529

Basic Information

CAS ID: 914913-88-5
Molecular Formula: C24H22O6
Molecular Weight: 406.4 g/mol
Monoisotopic Mass: 406.1416 g/mol
Class: Small Molecule
Natural Product: No
Other Names: Palomid-529 | P-529
Analysis: Drug repositioning mechanism analysis

O O O O O OH

Compound Structure and Identifier

InChI: InChI=1S/C24H22O6/c1-14(25)16-6-9-18-19-11-22(28-3)23(12-21(19)30-24(26)20(18)10-16)29-13-15-4-7-17(27-2)8-5-15/h4-12,14,25H,13H2,1-3H3 See All
InChI Key: YEAHTLOYHVWAKW-UHFFFAOYSA-N
Smiles: COc1ccc(COc2cc3OC(=O)c4cc(ccc4c3cc2OC)C(C)O)cc1 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0954 Phosphoinositide 3-kinase inhibitor
T1014 mTOR Complex 1 inhibitor
T1015 mTOR Complex 2 inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 28078713 Target ID T1014
Uniprot ID mTOR Complex 1 Name mTOR Complex 1
Model vitro,human Fibrosis Disease Liver fibrosis
Process I
Process II fibroblasts-to-myofibroblasts
Process III prevenet collagen deposition
Mechanism Targeting TGF-β signaling

Reference Record 2

PubMed ID 28078713 Target ID T1015
Uniprot ID mTOR Complex 2 Name mTOR Complex 2
Model vitro,human Fibrosis Disease Liver fibrosis
Process I
Process II fibroblasts-to-myofibroblasts
Process III prevenet collagen deposition
Mechanism Targeting TGF-β signaling

Reference Record 3

PubMed ID 22982188 Target ID T0954
Uniprot ID Phosphoinositide 3-kinase Name Phosphoinositide 3-kinase
Model vitro,human Fibrosis Disease Keloid
Process I attenue inflammation
Process II fibroblasts proliferation,fibroblasts migration,fibroblasts apoptosis
Process III prevenet collagen deposition
Mechanism Targeting PI3K/Akt/mTOR axis

Related Link

PubChem: 11998575
ChEMBL: CHEMBL2141712