Phosphoinositide 3-kinase

Basic Information

Uniprot ID:
Secondary ID:
Symbol:
Other Name:
Class: Protein Famliy
Type: pro-fibrotic
Molecular Function:

Target Classification

Category I Category II Category III
Other

Related Compound

Target ID Name Interaction
D0022 LY294002 inhibitor
D0089 Palomid 529 inhibitor
D0151 Omipalisib inhibitor
D0170 Dactolisib inhibitor
D0272 Sonolisib inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 27103349 Compound ID D0151
CAS 1086062-66-9 Name Omipalisib
Model vitro,human Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II fibroblasts proliferation
Process III
Mechanism

Reference Record 2

PubMed ID 25258031 Compound ID D0170
CAS 915019-65-7 Name Dactolisib
Model vitro,mice Fibrosis Disease Systemic sclerosis
Process I
Process II fibroblasts activation
Process III prevenet collagen deposition
Mechanism Targeting PI3K/Akt/mTOR

Reference Record 3

PubMed ID 24475138 Compound ID D0272
CAS 502632-66-8 Name Sonolisib
Model mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II cells proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 23444088 Compound ID D0022
CAS 154447-36-6 Name LY294002
Model mice Fibrosis Disease Muscle fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting PI3K-Akt-mTOR pathway

Reference Record 5

PubMed ID 22982188 Compound ID D0089
CAS 914913-88-5 Name Palomid 529
Model vitro,human Fibrosis Disease Keloid
Process I attenue inflammation
Process II fibroblasts proliferation,fibroblasts migration,fibroblasts apoptosis
Process III prevenet collagen deposition
Mechanism Targeting PI3K/Akt/mTOR axis

Reference Record 6

PubMed ID 19790269 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I
Process II HSCs proliferation,HSCs migration,HSCs apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 19519177 Compound ID D0022
CAS 154447-36-6 Name LY294002
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I
Process II fibroblasts activation
Process III
Mechanism Targeting PI3K-Akt pathway

Reference Record 8

PubMed ID 19434726 Compound ID D0022
CAS 154447-36-6 Name LY294002
Model vitro,human Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation,HSCs proliferation
Process III prevenet collagen deposition
Mechanism Targeting ERK 1/2 and PI3K-Akt pathways

Reference Record 9

PubMed ID 29170419 Compound ID D0022
CAS 154447-36-6 Name LY294002
Model vitro,human Fibrosis Disease Fibrosis
Process I
Process II cells proliferation
Process III
Mechanism