SB203580

Basic Information

CAS ID: 152121-47-6
Molecular Formula: C21H16FN3OS
Molecular Weight: 377.4 g/mol
Monoisotopic Mass: 377.0998 g/mol
Class: Small Molecule
Natural Product: No
Other Names: SB-203580
Analysis: Drug repositioning mechanism analysis

S+ O- N F NH N

Compound Structure and Identifier

InChI: InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) See All
InChI Key: CDMGBJANTYXAIV-UHFFFAOYSA-N
Smiles: C[S+]([O-])c1ccc(cc1)c2nc(c3ccc(F)cc3)c([nH]2)c4ccncc4 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0342 Mitogen-activated protein kinase 1 inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 25873302 Target ID T0342
Uniprot ID Mitogen-activated protein kinase 1 Name Mitogen-activated protein kinase 1
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I
Process II EMT
Process III
Mechanism Targeting MAPK signaling

Reference Record 2

PubMed ID 27314440 Target ID T0342
Uniprot ID Mitogen-activated protein kinase 1 Name Mitogen-activated protein kinase 1
Model vitro Fibrosis Disease Leptomeningeal fibrosis
Process I
Process II
Process III
Mechanism Targeting p38 signaling

Reference Record 3

PubMed ID 26227022 Target ID T0342
Uniprot ID Mitogen-activated protein kinase 1 Name Mitogen-activated protein kinase 1
Model vitro,human Fibrosis Disease Systemic sclerosis
Process I
Process II
Process III
Mechanism Targeting IL-13

Reference Record 4

PubMed ID 22900077 Target ID T0342
Uniprot ID Mitogen-activated protein kinase 1 Name Mitogen-activated protein kinase 1
Model vitro,mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 16841034 Target ID T0985
Uniprot ID p38 mitogen-activated protein kinases Name p38 mitogen-activated protein kinases
Model vitro Fibrosis Disease Keloid
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 26054450 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Keloid
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 12077559 Target ID T0985
Uniprot ID p38 mitogen-activated protein kinases Name p38 mitogen-activated protein kinases
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Related Link

PubChem: 176155
ChEMBL: CHEMBL10