Mitogen-activated protein kinase 1

Basic Information

Uniprot ID:	P28482
Secondary ID:	A8CZ64
Symbol:	MAPK1
Other Name:	ERK2,MAP kinase 1,MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAP kinase 2,MAPK 2
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	DNA-binding,Kinase,Repressor,Serine/threonine-protein kinase,Transferase

Target Classification

Category I	Category II	Category III
Intracellular	Enzyme	Kinase

Related Compound

Target ID	Name	Interaction
D0035	PD98059	inhibitor
D0110	SB203580	inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID	28616713	Compound ID	D0035
CAS	167869-21-8	Name	PD98059
Model	vitro	Fibrosis Disease	Fibrosis
Process I
Process II	EMT
Process III
Mechanism

Reference Record 2

PubMed ID	25873302	Compound ID	D0110
CAS	152121-47-6	Name	SB203580
Model	vitro	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II	EMT
Process III
Mechanism	Targeting MAPK signaling

Reference Record 3

PubMed ID	27314440	Compound ID	D0110
CAS	152121-47-6	Name	SB203580
Model	vitro	Fibrosis Disease	Leptomeningeal fibrosis
Process I
Process II
Process III
Mechanism	Targeting p38 signaling

Reference Record 4

PubMed ID	26227022	Compound ID	D0110
CAS	152121-47-6	Name	SB203580
Model	vitro,human	Fibrosis Disease	Systemic sclerosis
Process I
Process II
Process III
Mechanism	Targeting IL-13

Reference Record 5

PubMed ID	24303948	Compound ID	D0035
CAS	167869-21-8	Name	PD98059
Model	vitro,rat	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs proliferation,cells apoptosis
Process III
Mechanism

Reference Record 6

PubMed ID	22900077	Compound ID	D0110
CAS	152121-47-6	Name	SB203580
Model	vitro,mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID	17039283	Compound ID	D0035
CAS	167869-21-8	Name	PD98059
Model	vitro	Fibrosis Disease	Joint fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 8

PubMed ID	16871530	Compound ID	D0035
CAS	167869-21-8	Name	PD98059
Model	vitro,mice	Fibrosis Disease	Dermal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID	16289155	Compound ID	D0035
CAS	167869-21-8	Name	PD98059
Model	vitro	Fibrosis Disease	Keloid
Process I
Process II
Process III
Mechanism