Fasudil

Basic Information

CAS ID:	103745-39-7
Molecular Formula:	C14H17N3O2S
Molecular Weight:	291.4 g/mol
Monoisotopic Mass:	291.1041 g/mol
Class:	Small Molecule
Natural Product:	No
Other Names:	AT-877 \| ZK-258594 \| FASUDIL \| HA-1077 \| Fasudil
Analysis:	Drug repositioning mechanism analysis

Compound Structure and Identifier

InChI:	InChI=1S/C14H17N3O2S/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14/h1,3-5,7,11,15H,2,6,8-10H2	See All
InChI Key:	NGOGFTYYXHNFQH-UHFFFAOYSA-N
Smiles:	O=S(=O)(N1CCCNCC1)c2cccc3cnccc23	See All
Molfile:	Download

Related Target

Target ID	Name	Interaction
T0340	Rho-associated protein kinase 1	inhibitor
T0341	Rho-associated protein kinase 2	inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID	27576917	Target ID	T0340
Uniprot ID	Rho-associated protein kinase 1	Name	Rho-associated protein kinase 1
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID	26490279	Target ID	T0340
Uniprot ID	Rho-associated protein kinase 1	Name	Rho-associated protein kinase 1
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 3

PubMed ID	23812394	Target ID
Uniprot ID		Name
Model	vitro	Fibrosis Disease	Renal fibrosis
Process I
Process II	EMT
Process III
Mechanism	Targeting RhoA/ROCK signaling

Reference Record 4

PubMed ID	23615507	Target ID	T0340
Uniprot ID	Rho-associated protein kinase 1	Name	Rho-associated protein kinase 1
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting HIF-1α

Reference Record 5

PubMed ID	23615507	Target ID	T0341
Uniprot ID	Rho-associated protein kinase 2	Name	Rho-associated protein kinase 2
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting HIF-1α

Reference Record 6

PubMed ID	22942703	Target ID	T0340
Uniprot ID	Rho-associated protein kinase 1	Name	Rho-associated protein kinase 1
Model	mice	Fibrosis Disease	Idiopathic pulmonary fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID	22942703	Target ID	T0341
Uniprot ID	Rho-associated protein kinase 2	Name	Rho-associated protein kinase 2
Model	mice	Fibrosis Disease	Idiopathic pulmonary fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID	22166971	Target ID	T0340
Uniprot ID	Rho-associated protein kinase 1	Name	Rho-associated protein kinase 1
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID	22026130	Target ID
Uniprot ID		Name
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID	18356698	Target ID	T0340
Uniprot ID	Rho-associated protein kinase 1	Name	Rho-associated protein kinase 1
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID	18356698	Target ID	T0341
Uniprot ID	Rho-associated protein kinase 2	Name	Rho-associated protein kinase 2
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Related Link

PubChem:	3547
ChEMBL:	CHEMBL38380