Rho-associated protein kinase 2

Basic Information

Uniprot ID: O75116
Secondary ID: Q53QZ0, Q53SJ7, Q9UQN5
Symbol: ROCK2
Other Name: KIAA0619,Rho kinase 2,Rho-associated, coiled-coil-containing protein kinase 2,Rho-associated, coiled-coil-containing protein kinase II,ROCK-II,p164 ROCK-2
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Kinase,Serine/threonine-protein kinase,Transferase

Target Classification

Category I Category II Category III
Intracellular Enzyme Kinase

Related Compound

Target ID Name Interaction
D0125 Fasudil inhibitor
D0306 Y27632 inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 24675663 Compound ID
CAS Name
Model mice Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 23615507 Compound ID D0125
CAS 103745-39-7 Name Fasudil
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting HIF-1α

Reference Record 3

PubMed ID 22942703 Compound ID D0125
CAS 103745-39-7 Name Fasudil
Model mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 18356698 Compound ID D0125
CAS 103745-39-7 Name Fasudil
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 11967018 Compound ID D0306
CAS 146986-50-7 Name Y27632
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism Targeting Rho-ROCK signaling

Reference Record 6

PubMed ID 11961044 Compound ID D0306
CAS 146986-50-7 Name Y27632
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 11961044 Compound ID D0306
CAS 146986-50-7 Name Y27632
Model rat Fibrosis Disease Vascular fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID 11847192 Compound ID D0306
CAS 146986-50-7 Name Y27632
Model rat Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID 11394652 Compound ID D0306
CAS 146986-50-7 Name Y27632
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation
Process III prevenet collagen deposition
Mechanism Targeting Rho-ROCK pathway

Reference Record 10

PubMed ID 11208648 Compound ID D0306
CAS 146986-50-7 Name Y27632
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I attenue inflammation
Process II cells migration
Process III prevenet collagen deposition
Mechanism Targeting Rho/ROCK-mediated pathway